Publications

Human retina-in-a-dish: Unlocking the potential to study mechanisms of inherited retinal disease.

Yee T, Wert KJ, 2023 Sep Mol Ther Methods Clin Dev 30 573-575

Visual impairment cell non-autonomously dysregulates brain-wide proteostasis.

Shekhar S, Wert KJ, Krämer H, 2023 Oct bioRxiv

Murine Orchiectomy and Ovariectomy to Reduce Sex Hormone Production.

Rowe AA, Issioui Y, Johnny B, Wert KJ, 2023 Nov J Vis Exp 201

HIF2a activation and mitochondrial deficit due to iron chelation cause retinal atrophy.

Kong Y, Liu PK, Li Y, Nolan ND, Quinn PMJ, Hsu CW, Jenny LA, Zhao J, Cui X, Chang YJ, Wert KJ, Sparrow JR, Wang NK, Tsang SH, 2023 Jan EMBO Mol Med e16525

Base and Prime Editing in the Retina-From Preclinical Research toward Human Clinical Trials.

Yee T, Wert KJ, 2022 Oct Int J Mol Sci 20 23

Long-term progression of retinal degeneration in a preclinical model of CLN7 Batten disease as a baseline for testing clinical therapeutics.

Rowe AA, Chen X, Nettesheim ER, Issioui Y, Dong T, Hu Y, Messahel S, Kayani SN, Gray SJ, Wert KJ, 2022 Nov EBioMedicine 85 104314

Differential effects of obstructive sleep apnea on the corneal subbasal nerve plexus and retinal nerve fiber layer.

Bussan KA, Stuard WL, Mussi N, Lee W, Whitson JT, Issioui Y, Rowe AA, Wert KJ, Robertson DM, 2022 PLoS One 6 17 e0266483

Replenishment of TCA cycle intermediates provides photoreceptor resilience against neurodegeneration during progression of retinitis pigmentosa.

Rowe AA, Patel PD, Gordillo R, Wert KJ, 2021 Jul JCI Insight

Phenotypic variance in Calpain-5 retinal degeneration.

Tang PH, Chemudupati T, Wert KJ, Folk JC, Mahajan M, Tsang SH, Bassuk AG, Mahajan VB, 2020 Jun Am J Ophthalmol Case Rep 18 100627

Metabolite therapy guided by liquid biopsy proteomics delays retinal neurodegeneration.

Wert KJ, Velez G, Kanchustambham VL, Shankar V, Evans LP, Sengillo JD, Zare RN, Bassuk AG, Tsang SH, Mahajan VB, 2020 Feb EBioMedicine 52 102636

Insights into Retinal Development Using Live Imaging in Female Carriers of Choroideremia.

Wert KJ, Bakall B, Bassuk AG, Tsang SH, Mahajan VB, 2019 May Ophthalmic Surg Lasers Imaging Retina 5 50 e158-e162

CAPN5 genetic inactivation phenotype supports therapeutic inhibition trials.

Wert KJ, Koch SF, Velez G, Hsu CW, Mahajan M, Bassuk AG, Tsang SH, Mahajan VB, 2019 Aug Hum. Mutat.

Metabolite therapy guided by liquid biopsy proteomics delays retinal degeneration

Wert KJ, Velez G, Vijayalaksmi K, Shankar V, Sengillo JD, Zare RN, Bassuk AG, Tsang SH, Mahajan VB 2019

In Vivo Expression of Mutant Calpains in the Eye Using Lentivirus.

Wert KJ, Mahajan VB, 2019 Methods Mol. Biol. 1915 233-247

Extracellular superoxide dismutase (SOD3) regulates oxidative stress at the vitreoretinal interface.

Wert KJ, Velez G, Cross MR, Wagner BA, Teoh-Fitzgerald ML, Buettner GR, McAnany JJ, Olivier A, Tsang SH, Harper MM, Domann FE, Bassuk AG, Mahajan VB, 2018 08 Free Radic. Biol. Med. 124 408-419

Establishment of human pluripotent stem cell-derived pancreatic ?-like cells in the mouse pancreas.

Ma H, Wert KJ, Shvartsman D, Melton DA, Jaenisch R, 2018 04 Proc. Natl. Acad. Sci. U.S.A. 15 115 3924-3929

Cytotoxic Escherichia coli strains encoding colibactin isolated from immunocompromised mice with urosepsis and meningitis.

Bakthavatchalu V, Wert KJ, Feng Y, Mannion A, Ge Z, Garcia A, Scott KE, Caron TJ, Madden CM, Jacobsen JT, Victora G, Jaenisch R, Fox JG, 2018 PLoS ONE 3 13 e0194443

Human neural crest cells contribute to coat pigmentation in interspecies chimeras after in utero injection into mouse embryos.

Cohen MA, Wert KJ, Goldmann J, Markoulaki S, Buganim Y, Fu D, Jaenisch R, 2016 Feb Proc. Natl. Acad. Sci. U.S.A. 6 113 1570-5

Molecular Criteria for Defining the Naive Human Pluripotent State.

Theunissen TW, Friedli M, He Y, Planet E, O'Neil RC, Markoulaki S, Pontis J, Wang H, Iouranova A, Imbeault M, Duc J, Cohen MA, Wert KJ, Castanon R, Zhang Z, Huang Y, Nery JR, Drotar J, Lungjangwa T, Trono D, Ecker JR, Jaenisch R, 2016 10 Cell Stem Cell 4 19 502-515

Neuroretinal hypoxic signaling in a new preclinical murine model for proliferative diabetic retinopathy.

Wert KJ, Mahajan VB, Zhang L, Yan Y, Li Y, Tosi J, Hsu CW, Nagasaki T, Janisch KM, Grant MB, Mahajan M, Bassuk AG, Tsang SH, 2016 Signal Transduct Target Ther 1

Pathology and mechanism of eye diseases

Wert KJ, Kroeger H, Wu F, Tsang SH, Lin JH 2016 3-32

A Systematic Approach to Identify Candidate Transcription Factors that Control Cell Identity.

D'Alessio AC, Fan ZP, Wert KJ, Baranov P, Cohen MA, Saini JS, Cohick E, Charniga C, Dadon D, Hannett NM, Young MJ, Temple S, Jaenisch R, Lee TI, Young RA, 2015 Nov Stem Cell Reports 5 5 763-775

CAPN5 mutation in hereditary uveitis: the R243L mutation increases calpain catalytic activity and triggers intraocular inflammation in a mouse model.

Wert KJ, Bassuk AG, Wu WH, Gakhar L, Coglan D, Mahajan M, Wu S, Yang J, Lin CS, Tsang SH, Mahajan VB, 2015 Aug Hum. Mol. Genet. 16 24 4584-98

Functional validation of a human CAPN5 exome variant by lentiviral transduction into mouse retina.

Wert KJ, Skeie JM, Bassuk AG, Olivier AK, Tsang SH, Mahajan VB, 2014 May Hum. Mol. Genet. 10 23 2665-77

Silencing of tuberin enhances photoreceptor survival and function in a preclinical model of retinitis pigmentosa (an american ophthalmological society thesis).

Tsang SH, Chan L, Tsai YT, Wu WH, Hsu CW, Yang J, Tosi J, Wert KJ, Davis RJ, Mahajan VB, 2014 Jul Trans Am Ophthalmol Soc 112 103-15

Mid-stage intervention achieves similar efficacy as conventional early-stage treatment using gene therapy in a pre-clinical model of retinitis pigmentosa.

Wert KJ, Sancho-Pelluz J, Tsang SH, 2014 Jan Hum. Mol. Genet. 2 23 514-23

General pathophysiology in retinal degeneration.

Wert KJ, Lin JH, Tsang SH, 2014 Dev Ophthalmol 53 33-43

Gene therapy provides long-term visual function in a pre-clinical model of retinitis pigmentosa.

Wert KJ, Davis RJ, Sancho-Pelluz J, Nishina PM, Tsang SH, 2013 Feb Hum. Mol. Genet. 3 22 558-67

Therapeutic margins in a novel preclinical model of retinitis pigmentosa.

Davis RJ, Hsu CW, Tsai YT, Wert KJ, Sancho-Pelluz J, Lin CS, Tsang SH, 2013 Aug J. Neurosci. 33 33 13475-83

Subretinal injection of gene therapy vectors and stem cells in the perinatal mouse eye.

Wert KJ, Skeie JM, Davis RJ, Tsang SH, Mahajan VB, 2012 Nov J Vis Exp 69

Deoxygenation of aromatic ketones using transfer hydrogenolysis with Raney nickel in 2-propanol

Zuidema DR, Williams SL, Wert KJ, Bosma KJ, Smith AL, Mebane RC 2011 41 19 2927-2931

Transplantation of reprogrammed embryonic stem cells improves visual function in a mouse model for Retinitis Pigmentosa: Transplantation 2010 April 27;89 (8): 911-919.

Nan-Kai W, Tosi J, Kasanuki JM, Chou CL, Kong J, Parmalee N, Wert KJ, Allikmets R, Lai CC, Chien CL, Nagasaki T, Lin CS, Tsang SH, 2010 Oct Ann Neurosci 4 17 185-6

Transplantation of reprogrammed embryonic stem cells improves visual function in a mouse model for retinitis pigmentosa.

Wang NK, Tosi J, Kasanuki JM, Chou CL, Kong J, Parmalee N, Wert KJ, Allikmets R, Lai CC, Chien CL, Nagasaki T, Lin CS, Tsang SH, 2010 Apr Transplantation 8 89 911-9

A novel method of reducing ketones using sodium hydroxide in isopropanol

Zuidema DR, Wert KJ, Williams SL, Chill ST, Holte KL, Kokes NK, Mebane RC 2010 40 8 1187-1191