December 13, 2024
Nestor's work that expands the metabolites sensed by the BumSR TCS is published
Many praises to Nestor for his publication in mBio that expands the intestinal metabolites that are sensed by the BumS sensor phosphatase to include the branched short chain fatty acids isobutyrate and isovalerate. This work involved a great combination of genetics, biochemistry, bioinformatics and in vivo models of colonization. It was involved a wonderful collaboration between our lab, Chad Brautigam, Jiawei Xing and Igor Zhulin.
November 2024
Amanda is Awarded an NIH F31 Fellowship!
A wonderful achievement by Amanda! She wrote an excellent proposal and was awarded an NIH F31 Fellowship to support her research on unique proteins in Camylobacter jejuni that are required to form the flagellum. Job well done!
October 2024
Alexis's Work on How FlaG Controls Flagellar Filament Length in C. jejuni and Other Polar Flagellates is Published in PNAS!
We are excited that Alexis's research describing a mechanism for how polarly flagellated bacteria employ the FlaG protein to control flagellar filament length is published in PNAS. This project took some interesting twists and turns, but we ultimately found that FlaG interacts with FlhA in the fT3SS to antagonize FliS docking to FlhA to reduce flagellin secretion for filament polymerization. This could explain why polarly flagellated bacteria tend to produce shorter flagellar filaments than their peritrichous counterparts. Kudos to Alexis!
November 2023
Deb's Viscosity-Dependent Swimming Velocity Alterations Manuscript is accepted in mBio!
Congrats to Deb for a great piece of work describing the high velocity swimming motility in high viscosity conditions that also suggest that the C. jejuni flagellar motor naturally evolved for high velocity swimming through viscous conditions. Through genetics, suppressor screens, and dark-field microscopy, Deb identified the VidA and VidB proteins that function to reduce swimming velocity in low viscosity environments. This was a fun journey!
July 2023
Angela joins the lab
A hearty welcome to Dr. Angela Freeman! Angela joins the lab as a Research Associate. We wish the best for her as she begins her adventures in Campylobacter research!
June 2023
Celebrating Deb's 25 years of service to the University of Texas system
What an accomplishment! Congratulations to Deb as a member of Quarter-Century Club. Deb reached this achievement by being a part of the University of Texas team for 25 years! We appreciate all of her hard work and loyalty to the research team and the university system.
May 2023
Amanda passes her qualifying exam
Congratulations to Amanda for passing her qualifying exam. She is now a PhD candidate and on her road to success!
September 2022
Deb presents her research at the Signal Transduction in Microorganisms Gordon Conference
Deb gave an excellent talk about her research on how the swimming velocity of C. jejuni is altered in a viscosity-dependent manner and the factors that mediate this process for the bacterial cell. Such a great series of experiments analyzing a unique aspect of C. jejuni flagellar motility.
January 2022
Amanda joins the research team
Amanda Dobbins joins the lab as the 12th graduate student in the history of the Hendrixson lab. We expect only great things from the research that Amanda will perform in the laboratory!
July 2021
The Lab wins Silver at the Micro Olympics
The Hendrixson Lab takes silver in the 2021 Micro Summer Olympics! The entire lab competed well in multiple events and won the Silver Medal (or Trophy), a basket of goodies, and a lab lunch! Good times were had and a great performance from the lab! Plus, we made some awesome Lab T-shirts - thanks, Deb!
July 2021
An NIH R01 is renewed again
The lab renews an NIH R01 to continue to study the molecular mechanisms of flagellar biogenesis and function in polarly-flagellated bacterial pathogens. This continued funding is the result of a lot of hard work by many great graduate students and research scientists over the years. It takes a great cooperative and interactive team to sustain this level of funding for 20 years!
May 2021
Alexis and Nestor successfully pass qualifying exams
Alexis and Nestor passed their qualifying exams! Both of these great students are now Ph.D. candidates. Great research and fantastic outcomes are ahead!
September 2020
Peter defends his Ph.D thesis
Peter successfully defends his Ph.D thesis! Congrats, Peter! Next, he is off to the University of Wisconsin for his post-doctoral fellowship.
June 2020
Dave does a microTalk podcast
Dave does a podcast for microTalk that is sponsored by ASM and STCEID. Thanks to Karl Klose, Janakiram Seshu, and Mylea Echazarreta for the invitation and the fun time recording this podcast. Be sure to check out this great podcast series as this fantastic team interviews a wonderful array of microbiologists about many interesting topics.
Check out the PodcastMay 2020
Kyle defends his PhD
It's one degree down and one to go for Kyle! Kyle successfully defended his Ph.D. thesis today. Now it's back to med school for the MD! Best of luck, Kyle!
April 2020
Kyle's manuscript about butyrate sensing by C. jejuni is accepted for publication
Kyle's collaboration with Stephen Trent's laboratory identifying Campylobacter jejuni BumSR as a two-component signal transduction system that mediates a response to intestinal butyrate is accepted for publication in PNAS! This work also describes an unusual biochemical mechanism in bacterial signal transduction systems that employs phosphatase activity in response to the detection of a signal. Also, check out the press release from UT Southwestern.
Read Kyle's manuscriptFebruary 2020
Alexis and Nestor join the lab
Welcome, Alexis and Nestor! Alexis Waller and Nestor Ruiz join the laboratory as new graduate research assistants. We are excited to work with them over the next few years and can't wait to learn about the new discoveries they are sure to uncover!
January 2020
Peter's Paper Accepted for Publication in mBio
Peter's manuscript describing a conserved signal transduction system to mediate the polar flagellar transcriptional program across polar flagellates including Vibrio cholerae, Pseudomonas aeruginosa, and Campylobacter jejuni is accepted for publication in mBio! This was a massive amount of work that also combined silico analysis, genetics, electron microscopy, and other approaches. Congrats, Peter!
Check out the ManuscriptNovember 2019
A New Collaborative Publication between the Hendrixson and Beeby Labs
Our continued collaboration with the laboratory of Morgan Beeby has resulted in another publication! This work just accepted to mBio describes the unusual architecture, composition, and function of the Campylobacter jejuni flagellar C ring. We appreciate the combined efforts of Louie, Teige, Morgan, Deb, CJ, and Dave!
Read the new collaborationAugust 2019
The Hendrixson Lab Receives a New R01
The lab is awarded a new NIH R01 grant to analyze the ability of Campylobacter jejuni to sense and respond to microbiota-generated metabolites in the intestines of hosts! We are very grateful for this grant as it represents a lot of hard work over many years by many folks in the laboratory. We anticipate many new findings are just over the horizon!
July 2019
Deb's Analysis of C. jejuni FlgX Accepted for Publication
Deb's paper on the role of FlgX as a chaperone for the stators of the Campylobacter jejuni flagellar motor is accepted for publication by mBio! The paper is a great piece of work.
Read Deb's publicationSeptember 2018
Peter's review is published
Peter's review about Campylobacter jejuni biology and host interactions is published in Nature Reviews Microbiology! We appreciate the invitation from the editors!
Check out Peter's reviewSeptember 2017
Joe opens his lab
Former Ph.D. student, Joe Boll, begins his faculty position and opens his laboratory at the University of Texas at Arlington. We are proud that Joe is a fellow colleague in the area!
August 2017
Kyle joins the lab
Kyle Goodman, a MSTP student, has joined the lab. We are eager to see what great new things Kyle will find out about C. jejuni!
August 2017
Paul starts his faculty position
Former Ph.D. student Paul Luethy begins his professional career as an Assistant Professor of Pathology at the University of Maryland School of Medicine and Associate Director of Microbiology at the University of Maryland Medical Center. We expect you will do great things in this position!
July 2017
Paul's paper is highlighted
Paul's mBio paper describing evidence for Campylobacter jejuni sensing in vivo spatial gradients of short-chain fatty acids to affect colonization of hosts is highlighted in Nature Reviews Microbiology.
Read Paul's paperJune 2017
Peter passes his qualifying exam
Congrats to Peter for passing his qualifying exam! Onward towards some great research and the Ph.D. thesis!
April 2017
Paul's paper is accepted at mBio
Paul's second manuscript that describes uncovering evidence for Campylobacter jejuni sensing in vivo gradients of short-chain fatty acids and organic acids to influence its ability to colonize the avian host is accepted for publication at mBio! We are looking forward to more exploration into this aspect of C. jejuni biology.
Check out Paul's manuscriptMarch 2016
High-torque flagellar motor structures revealed in our PNAS publication
A multi-laboratory collaboration involving the Beeby, Ruby, Jensen, and Hendrixson Laboratories has resulted in a PNAS publication revealing our structural analysis of the high-torque flagellar motors of Campylobacter jejuni and Vibrio fischeri. This was a wonderful collaborative experience with these labs!
Read the multi-laboratory collaborationMarch 2016
CJ successfully defends his PhD thesis!
CJ defends his Ph.D. thesis! Onward to the USDA/ARS for a post-doctoral fellowship in microscopy!
March 2016
Peter joins the lab
Peter Burnham joins the lab as a graduate student. We are excited to have Peter as a part of our team!
October 2015
CJ's first paper accepted for publication
CJ’s work on how FlhG contributes to regulation of flagellar number in C. jejuni has been accepted for publication at Molecular Microbiology.
Read CJ's first paperSeptember 2015
Will Kolar joins lab
Will Kolar joins the laboratory as our newest research assistant. Welcome, Will!
July 2015
Mickey TeKippe receives the WW Caruth Fellow Research Award
Mickey TeKippe receives the WW Caruth Fellow Research Award! Congrats, Mickey!
May 2015
Paul defends his Ph.D. thesis
May 13, 2015 – Paul defends his Ph.D. thesis. A great end and an exciting new beginning at the NIH awaits!
February 2015
Paul’s manuscript accepted in the Journal of Bacteriology
February 11, 2015 – Paul’s manuscript, “Analysis of the Activity of the Two-component Regulatory System Composed by Cjj1484 and Cjj1483 of Campylobacter jejuni”, is accepted in the Journal of Bacteriology.
Check out the ManuscriptJanuary 2015
Mickey TeKippe joins the Hendrixson and Greenberg labs
January 2, 2015 – Mickey TeKippe joins the Hendrixson and Greenberg Lab’s as a Pediatric Infectious Disease Fellow. We expect many great things ahead from his research.
July 2014
Angelica’s manuscript accepted for publication in Molecular Microbiology
July 8, 2014 – Angelica’s manuscript entitled “Flagellar Biosynthesis Exerts Temporal Regulation of Secretion of Specific Campylobacter jejuni Colonization and Virulence Determinants” is accepted for publication in Molecular Microbiology!
Check out Angelica’s manuscriptOctober 2013
Angelica successfully defends thesis
October 11, 2013 – Angelica successfully defended her thesis. Onward to UNC!
October 2013
Deb receives a UT Southwestern Medical Center PACT award
October 8, 2013 – Deb receives a UT Southwestern Medical Center PACT award, which recognizes staff who exhibit exceptional service to co-workers and provide outstanding teamwork and collaboration. Deb received this award for her commitment to the North Campus Recycling Program.
August 2013
Joe’s manuscript accepted at mBio
August 5, 2013 – Joe’s manuscript, “A Regulatory Checkpoint during Flagellar Biogenesis in Campylobacter jejuni Initiates Signal Transduction to Activate Transcription of Flagellar Genes”, is accepted at mBio!
April 2013
Joe defends his thesis
Joe defends his thesis. Moving down the road to UT Austin… we wish you the best in science and success!
April 2012
CJ Enters Ph.D. Candidacy
April 26, 2012 – CJ successfully passes his Qualifying Exam and enters Ph.D. candidacy!
April 2012
Paul passes his Qualifying Exam and enters Ph.D. candidacy
February 2012
Angelica’s manuscript accepted in Molecular Microbiology
February 12, 2012 – Angelica’s manuscript, “Identification and Analysis of Flagellar Co-expressed Determinants (Feds) of Campylobacter jejuni Involved in Colonization”, is accepted in Molecular Microbiology!
Read Angelica’s manuscript in Molecular MicrobiologyDecember 2011
Murat’s work named a Faculty of 1000 selection
December 15, 2011 – Murat’s work “Polar Flagellar Biosynthesis and a Regulator of Flagellar Number Influence Spatial Parameters of Division in Campylobacter jejuni” (PLoS Pathogen [2008]) is named a Faculty of 1000 selection.
Read Murat’s workDecember 2011
Joe’s manuscript is published in PNAS
December 13, 2011 - Joe’s manuscript, “A Specificity Determinant for Phosphorylation in a Response Regulator Prevents in vivo Cross-talk and Modification by Acetyl Phosphate”, is published in PNAS!
Check out Joe’s manuscriptOctober 2011
Murat’s manuscript accepted in PLoS Pathogens
October 20, 2011 – Murat’s manuscript entitled “Polar Flagellar Biosynthesis and a Regulator of Flagellar Number Influence Spatial Parameters of Cell Division in Campylobacter jejuni” is accepted in PLoS Pathogens!
Check out the manuscript in PLoS PathogensMarch 2011
Murat Successfully Defends Thesis
March 28, 2011 – Murat successfully defends his thesis. Watch out Sweden, Murat is on his way!
March 2011
Angelica successfully passes her Qualifying Exam and enters Ph.D. candidacy
March 22, 2011 – Angelica successfully passes her Qualifying Exam and enters Ph.D. candidacy.
March 2011
Paul joins the lab as a graduate research assistant
March 9, 2011 – Paul joins the lab as a graduate research assistant.
January 2011
Joe presents his research at the BLAST XI Meeting in New Orleans, LA
January 17, 2011 – Joe presents his research at the BLAST XI Meeting in New Orleans, LA.
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