Zhang Z, Gibson JR, Huber KM Experience-dependent weakening of callosal synaptic connections in the absence of postsynaptic FMRP. Elife 2021 Oct 7;10:e71555


Shah S, Molinaro G, Liu B, Wang R, Huber KM, Richter JD FMRP Control of Ribosome Translocation Promotes Chromatin Modifications and Alternative Splicing of Neuronal Genes Linked to Autism.Cell Rep 2020 Mar 30 13 4459-4472.e6

McCamphill PK, Stoppel LJ, Senter RK, Lewis MC, Heynen AJ, Stoppel DC, Sridhar V, Collins KA, Shi X, Pan JQ, Madison J, Cottrell JR, Huber KM, Scolnick EM, Holson EB, Wagner FF, Bear MF, Selective inhibition of glycogen synthase kinase 3a corrects pathophysiology in a mouse model of fragile X syndrome. Sci Transl Med 2020 May 12 544

Hien A, Molinaro G, Liu B, Huber KM, Richter JD, Ribosome profiling in mouse hippocampus: plasticity-induced regulation and bidirectional control by TSC2 and FMRP. Mol Autism 2020 Oct 11 1 78


Gonzalez D, Tomasek M, Hays S, et al. Audiogenic Seizures in the Fmr1 Knock-Out Mouse Are Induced by Fmr1 Deletion in Subcortical, VGlut2-Expressing Excitatory Neurons and Require Deletion in the Inferior Colliculus. J Neurosci. 2019;39(49):9852‐9863. doi:10.1523/JNEUROSCI.0886-19.2019

Goswami S, Cavalier S, Sridhar V, Huber KM, Gibson JR. Local cortical circuit correlates of altered EEG in the mouse model of Fragile X syndrome. Neurobiol Dis. 2019;124:563‐572. doi:10.1016/j.nbd.2019.01.002


Huber KM. Synaptic homeostasis: quality vs. quantity. Nat Neurosci. 2018;21(6):774‐776. doi:10.1038/s41593-018-0159-4

Wilkerson JR, Albanesi JP, Huber KM. Roles for Arc in metabotropic glutamate receptor-dependent LTD and synapse elimination: Implications in health and disease. Semin Cell Dev Biol. 2018;77:51‐62. doi:10.1016/j.semcdb.2017.09.035


Chang CW, Wilkerson JR, Hale CF, Gibson JR, Huber KM. Distinct stages of synapse elimination are induced by burst firing of CA1 neurons and differentially require MEF2A/D. Elife. 2017;6:e26278. Published 2017 Sep 13. doi:10.7554/eLife.26278

Tsai NP, Huber KM. Protocadherins and the Social Brain. Biol Psychiatry. 2017;81(3):173‐174. doi:10.1016/j.biopsych.2016.10.025

Tsai NP, Wilkerson JR, Guo W, Huber KM. FMRP-dependent Mdm2 dephosphorylation is required for MEF2-induced synapse elimination. Hum Mol Genet. 2017;26(2):293‐304. doi:10.1093/hmg/ddw386

Rajkovich KE, Loerwald KW, Hale CF, Hess CT, Gibson JR, Huber KM. Experience-Dependent and Differential Regulation of Local and Long-Range Excitatory Neocortical Circuits by Postsynaptic Mef2c. Neuron. 2017;93(1):48‐56. doi:10.1016/j.neuron.2016.11.022


Guo W, Molinaro G, Collins KA, et al. Selective Disruption of Metabotropic Glutamate Receptor 5-Homer Interactions Mimics Phenotypes of Fragile X Syndrome in Mice. J Neurosci. 2016;36(7):2131‐2147. doi:10.1523/JNEUROSCI.2921-15.2016


Guo W, Ceolin L, Collins KA, Perroy J, Huber KM. Elevated CaMKIIα and Hyperphosphorylation of Homer Mediate Circuit Dysfunction in a Fragile X Syndrome Mouse Model. Cell Rep. 2015;13(10):2297‐2311. doi:10.1016/j.celrep.2015.11.013

Loerwald KW, Patel AB, Huber KM, Gibson JR. Postsynaptic mGluR5 promotes evoked AMPAR-mediated synaptic transmission onto neocortical layer 2/3 pyramidal neurons during development. J Neurophysiol. 2015;113(3):786‐795. doi:10.1152/jn.00465.2014


Wilkerson JR, Tsai NP, Maksimova MA, et al. A role for dendritic mGluR5-mediated local translation of Arc/Arg3.1 in MEF2-dependent synapse elimination. Cell Rep. 2014;7(5):1589‐1600. doi:10.1016/j.celrep.2014.04.035

Patel AB, Loerwald KW, Huber KM, Gibson JR. Postsynaptic FMRP promotes the pruning of cell-to-cell connections among pyramidal neurons in the L5A neocortical network. J Neurosci. 2014;34(9):3413‐3418. doi:10.1523/JNEUROSCI.2921-13.2014


Jakkamsetti V, Tsai NP, Gross C, et al. Experience-induced Arc/Arg3.1 primes CA1 pyramidal neurons for metabotropic glutamate receptor-dependent long-term synaptic depression. Neuron. 2013;80(1):72‐79. doi:10.1016/j.neuron.2013.07.020


Tsai NP, Wilkerson JR, Guo W, et al. Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95. Cell. 2012;151(7):1581‐1594. doi:10.1016/j.cell.2012.11.040

Niere F, Wilkerson JR, Huber KM. Evidence for a fragile X mental retardation protein-mediated translational switch in metabotropic glutamate receptor-triggered Arc translation and long-term depression. J Neurosci. 2012;32(17):5924‐5936. doi:10.1523/JNEUROSCI.4650-11.2012


Hays SA, Huber KM, Gibson JR. Altered neocortical rhythmic activity states in Fmr1 KO mice are due to enhanced mGluR5 signaling and involve changes in excitatory circuitry. J Neurosci. 2011;31(40):14223‐14234. doi:10.1523/JNEUROSCI.3157-11.2011


Pfeiffer BE, Zang T, Wilkerson JR, et al. Fragile X mental retardation protein is required for synapse elimination by the activity-dependent transcription factor MEF2. Neuron. 2010;66(2):191‐197. doi:10.1016/j.neuron.2010.03.017


Waung, M.W., Pfeiffer, B.E., Nosyreva, E.D., Ronesi, J.A. and Huber, K.M. (2008) Rapid translation of Arc/Arg3.1 selectively mediates mGluR dependent LTD through persistent increases in AMPAR endocytosis rateNeuron, 59(1):84-97.

Gibson, J.R., Bartley, A.F., Hays, S. and Huber, K.M. (2008) An imbalance of neocortical excitation and inhibition and altered UP states reflect network hyperexcitability in the mouse model of Fragile X SyndromeJournal of Neurophysiology, 100(5):2615-26.

Ronesi, J.A. and Huber, K.M. (2008) Homer interactions are necessary for mGluR-induced long-term depression and translational activationJournal of Neuroscience, 28(2):543-7.


Volk, L. J., Pfeiffer, B.E, Gibson, J.R. and Huber, K.M. (2007) Multiple Gq-coupled receptors converge upon a common protein synthesis- dependent LTD that is affected in Fragile X syndrome mental retardationJournal of Neuroscience, 27(43):11624-34.

Pfeiffer, B.E., and Huber, K.M. (2007) Fragile X Mental Retardation Protein induces synapse loss through acute postsynaptic translational regulationJournal of Neuroscience, 27(12):3120-30. Highlighted in Nature Reviews Neuroscience, May 2007.


Gibson, J.R., Bartley, A. and Huber, K.M. (2006) A Role for the Subthreshold Currents ILeak and IH in the Homeostatic Control of Excitability in Neocortical Somatostatin-Positive Inhibitory Neurons Journal of Neurophysiology, 96(1):420-32.

Nosyreva E. N. and Huber K.M. (2006) Metabotropic glutamate receptor dependent long-term depression persists in the absence of protein synthesis in the mouse model of Fragile X Syndrome Journal of Neurophysiology, 95(5): 3291-5.

Volk, L, Daly, C.A., and Huber K.M. (2006) Differential roles for group 1 mGluR subtypes in induction and expression of chemically-induced hippocampal long-term depressionJournal of Neurophysiology, 95(4): 2427-38.


Nosyreva, E.N. and Huber, K.M. (2005) Developmental switch in mechanisms of hippocampal metabotropic glutamate receptor dependent synaptic plasticityJournal of Neuroscience, 25(11): 2992-3001.


Gallagher, S.M. Daly, C.A., Bear, M.F. and Huber, K.M. (2004) Extracellular signal-regulated protein kinase activation is required for metabotropic glutamate receptor -dependent long-term depression in hippocampal area CA1Journal of Neuroscience, 24(20):4859-64.


Huber, K.M., Gallagher, S., Warren, S.T. and Bear, M.F. (2002) Altered synaptic plasticity in a mouse model of fragile X mental retardationProc. Natl. Acad. Sci., 99(11): 7746-7750.


Huber, K.M., Kayser, M.S. and M.F. Bear. (2000) Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent LTDScience, 288(5469):1254-1257.

Complete list of Dr. Huber’s publications