Featured Publications
eIF5B drives integrated stress response-dependent translation of PD-L1 in lung cancer
Suresh S, Chen B, Zhu J, Golden RJ, Lu C, Evers BM, Novaresi N, Smith B, Zhan X, Schmid V, Jun S, Karacz CM, Peyton M, Zhong L, Wen Z, Sathe AA, Xing C, Behrens C, Wistuba II, Xiao G, Xie Y, Fu Y-X, Minna JD, Mendell JT, O'Donnell KA 2020 5 1 533-545Modulation of mutant KrasG12D-driven lung tumorigenesis in vivo by gain or loss of PCDH7 function
Zhou X, Padanad M, Evers BM, Smith B, Novaresi N, Suresh S, Richardson JA, Stein E, Zhu J, Hammer RE, O'Donnell KA 2019 594-603
Updegraff BL, Zhou X, Guo Y, Padanad MS, Chen PH, Yang C, Sudderth J, Rodriguez-Tirado C, Girard L, Minna JD, Mishra P, DeBerardinis RJ, O'Donnell KA
2018 Nov
Cell Rep
8
25
2223-2233.e6
SRC-2-mediated coactivation of anti-tumorigenic target genes suppresses MYC-induced liver cancer.
Suresh S, Durakoglugil D, Zhou X, Zhu B, Comerford SA, Xing C, Xie XJ, York B, O'Donnell KA 2017 Mar PLoS Genet. 3 13 e1006650
Zhou X, Updegraff BL, Guo Y, Peyton M, Girard L, Larsen JE, Xie XJ, Zhou Y, Hwang TH, Xie Y, Rodriguez-Canales J, Villalobos P, Behrens C, Wistuba II, Minna JD, O'Donnell KA
2016 Nov
Cancer Res.
Guo Y, Updegraff BL, Park S, Durakoglugil D, Burton V, Maddux S, Hwang TH, O'Donnell KA
2015 Dec
Cancer Res.
O'Donnell KA, Keng VW, York B, Reineke EL, Seo D, Fan D, Silverstein KA, Schrum CT, Xie WR, Mularoni L, Wheelan SJ, Torbenson MS, O'Malley BW, Largaespada DA, Boeke JD
2012 May
Proc. Natl. Acad. Sci. U.S.A.
21
109
E1377-86
Mobilizing diversity: transposable element insertions in genetic variation and disease.
O'Donnell KA, Burns KH 2010 Mob DNA 1 1Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model.
Kota J, Chivukula RR, O'Donnell KA, Wentzel EA, Montgomery CL, Hwang HW, Chang TC, Vivekanandan P, Torbenson M, Clark KR, Mendell JR, Mendell JT 2009 Jun Cell 6 137 1005-17
O'Donnell KA, Boeke JD
2007 Apr
Cell
1
129
Activation of transferrin receptor 1 by c-Myc enhances cellular proliferation and tumorigenesis.
O'Donnell KA, Yu D, Zeller KI, Kim JW, Racke F, Thomas-Tikhonenko A, Dang CV 2006 Mar Mol. Cell. Biol. 6 26 2373-86
Dang CV, O'donnell KA, Juopperi T
2005 Sep
Cancer Cell
3
8
O'Donnell KA, Wentzel EA, Zeller KI, Dang CV, Mendell JT
2005
7043
435
839-43
Park SK, Zhou X, Pendleton KE, Hunter OV, Kohler JJ, O'Donnell KA, Conrad NK
2017 Aug
Cell Rep
5
20
1088-1099
Hepatoblastoma modeling in mice places Nrf2 within a cancer field established by mutant ?-catenin.
Comerford SA, Hinnant EA, Chen Y, Bansal H, Klapproth S, Rakheja D, Finegold MJ, Lopez-Terrada D, O'Donnell KA, Tomlinson GE, Hammer RE 2016 Oct JCI Insight 16 1 e88549A role for retrotransposon LINE-1 in fetal oocyte attrition in mice.
Malki S, van der Heijden GW, O'Donnell KA, Martin SL, Bortvin A 2014 Jun Dev. Cell 5 29 521-533Controlled insertional mutagenesis using a LINE-1 (ORFeus) gene-trap mouse model.
O'Donnell KA, An W, Schrum CT, Wheelan SJ, Boeke JD 2013 Jul Proc. Natl. Acad. Sci. U.S.A. 29 110 E2706-13
Updegraff BL and O'Donnell KA
2013
PLoS Genetics
9
12
e1004045
Characterization of a synthetic human LINE-1 retrotransposon ORFeus-Hs.
An W, Dai L, Niewiadomska AM, Yetil A, O'Donnell KA, Han JS, Boeke JD 2011 Mob DNA 1 2 2Plug and play modular strategies for synthetic retrotransposons.
An W, Davis ES, Thompson TL, O'Donnell KA, Lee CY, Boeke JD 2009 Nov Methods 3 49Domesticated DNA transposon proteins mediate retrotransposon control.
O'Donnell KA, Boeke JD 2008 Mar Cell Res. 3 18A descent into the nuage: the maelstrom of transposon control.
O'Donnell KA, Burns KH, Boeke JD 2008 Aug Dev. Cell 2 15
Ben-Aroya S, Coombes C, Kwok T, O'Donnell KA, Boeke JD, Hieter P
2008 Apr
Mol. Cell
2
30
Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis.
Li F, Wang Y, Zeller KI, Potter JJ, Wonsey DR, O'Donnell KA, Kim JW, Yustein JT, Lee LA, Dang CV 2005 Jul Mol. Cell. Biol. 14 25 6225-34An mRNA surveillance mechanism that eliminates transcripts lacking termination codons.
Frischmeyer PA, van Hoof A, O'Donnell K, Guerrerio AL, Parker R, Dietz HC 2002 Mar Science 5563 295