Search All Lab Content

The CDR Collaborative studies last mile delivery problems across the cancer control continuum to develop and implement solutions.

We seek to understand how cancer cells harness the cytoskeleton to promote tumor growth, drug resistance and cancer metastasis through non-genetic, morphologic signaling programs.

The Lin Lab studies the transformation of brief experiences into enduring memories, their impact on behaviors, and the differing responses seen in both healthy and diseased conditions. Utilizing a multidisciplinary approach, our research explores how experience-induced genetic programs establish connections between experiences and synaptic modifications within neural circuits, ultimately driving persistent behavioral changes.

The Hattori lab studies how neural circuits integrate sensorimotor information, memory, and internal state to guide behavior.

Our group initially investigated a novel immune checkpoint inhibitor targeting a rare heparan sulfate (rHS) in melanoma treatment. Collaboratively, we explored the potential of a single-domain humanized rHS antibody (1A7 clone) that inhibits DC-HIL function and also angiogenesis and chemokine effects linked to diverse cancer progression signaling pathways. This experience provided insights into rHS-targeting as a promising approach to melanoma therapy.

The overall goal of our laboratory is to discover the processes in endothelial cells that govern cardiovascular and metabolic health and disease. 

The Louros Lab uses a hybrid approach combining molecular biophysics, structural biology, and bioinformatics to investigate protein stability, misfolding, and aggregation, with a particular interest in neurodegenerative diseases.

We study bacterial RNA polymerase function and regulation.

The Noch Lab is a basic and translational research laboratory focused on identifying novel strategies to target metabolic vulnerabilities in glioma.

The Varadarajan Lab is interested in rebuilding neural circuits and restoring sensory function impaired by injury or disease.

MUDIA Lab is focused on developing novel quantitative MRI techniques and analysis methods on CNS and musculoskeletal system. 

Our laboratory is interested in understanding how the ubiquitin-mediated protein degradation regulates gene expression and how failure of these pathways contributes to developmental disorders and diseases, such as neurodegeneration and cancer.

Qi lab specializes in investigating the structure and function of membrane proteins related to human diseases using cryo-EM, cell-based assays, and mouse models.

The Ishii Laboratory is interested in understanding the bidirectional relationship between brain function and systemic metabolism with an emphasis on metabolic deficits in Alzheimer’s disease and how it differs from normal aging. Our laboratory focuses on generating hypotheses derived from open questions in clinical neurology and neuroendocrinology, testing these hypotheses using molecular genetics and neuroscience techniques in the laboratory, and whenever possible verifying these findings in clinically relevant human research studies. 

Our research focuses on developing and testing novel immunotherapies for meningiomas (the most common brain tumors in adults) as well as on understanding the tumor immune microenvironment of meningiomas and other skull base tumors.

We unite researchers with diverse expertise in computational modeling, biochemical reconstitution, structural analysis of polymers, and cell biology to focus on three distinct condensates that are important for genome homeostasis.

Our laboratory has a particular interest in hepatic metabolism and its regulation by the immune system. We utilize genetic, epigenetic and proteomic approaches, combined with detailed physiological studies, to understand the complex mechanisms that causally link inflammation to metabolic dysfunction in obesity and fatty liver disease.

Research in Dr. Crandall's Thermal and Vascular Physiology Laboratory focuses on neural control of the cardiovascular system and how different stressors influence that control in healthy, diseased, and injured individuals, such as:

• Identifying the consequences of severe burn injuries and subsequent skin grafting on the ability of the burn survivor to regulate internal temperature and cardiovascular function.
• Understanding the consequences of aging on cardiovascular stress during simulated heat waves.
• Exploring cooling modalities to attenuate thermal and cardiovascular stress.
• Understanding how analgesics used on the battlefield affect autonomic control of blood pressure during hemorrhage.

The global focus of the Cardiovascular Physiology Autonomic Function Laboratory is to examine the adaptive capacity of the circulation.

• We study the effects of exercise training, bed rest deconditioning, spaceflight, high altitude, aging, and the effects of cardiovascular diseases, such as heart failure.
• By using sophisticated tools to assess cardiovascular structure and function, our research team brings "Olympic" and "space age" science to the solution of common clinical problems such as fainting, hypertension, or patients with shortness of breath. 
• We focus on measuring how the cardio-respiratory system distributes oxygen from the environment to the muscles.
• Our facility is one of the few labs in the world that can measure the limitations to exercise capacity at every step along the "oxygen cascade" - including the lungs, heart and muscles.
• We use invasive and non-invasive tools to assess cardiovascular structure and function, as well as circulatory control mechanisms.

The global focus of the Pulmonary Physiology Laboratory is the study of pulmonary exercise physiology, particularly as it pertains to pulmonary disease, normal aging, obesity, ventilatory control during exercise, applied respiratory physiology, and clinical cardiopulmonary exercise testing. The Lab consists of three separate investigative laboratories: the pulmonary function laboratory, the cardiopulmonary exercise physiology laboratory, and the body composition laboratory including DEXA imaging for the determination of percent body fat, lean body mass, bone content, visceral fat, overall fat distribution, and their effects on breathing.