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Our mission is to design and develop original devices, software solutions, and combined unique methodologies that translate into discoveries for next generation care.

We are interested in understanding the deregulation of epigenetic and transcriptional pathways in human disease and in finding small molecules with therapeutic potential to normalize these gene expression patterns. 

Our work advocates for the wider adoption of alteplase, antiplatelet therapy in ischemic stroke, secondary stroke prevention, off-label guidelines for those with acute ischemic stroke, and more.

The Neuro-Oncology Translational Research Laboratory studies primary brain tumors from pure basic science through the continuum to clinical trials. 

Leveraging cutting-edge genetic and chemical screens to uncover novel and enhanced therapeutics for cancer treatment.

The Molecular Imaging and Precision Medicine Lab has four Technology Research and Development (TR&D) projects that provide a platform on which new technology is developed and disseminated. The TR&Ds are complementary and integrated and extend from the development of reagents to detect and promote an immune reactive tumor microenvironment to the synthesis of nanodrones to treat cancer and combined small-molecule diagnostic and therapeutics (theranostic agents). We focus on generation of next-generation precision platforms, tools and techniques for tackling problems at the forefront of biomedical research with a focus on those that will lead to near-term translation.

The Rosa-Neto Lab studies the structural changes that occur in the brain as a result of neurodegenerative disease, such as Alzheimer’s disease. 

Research lab of Dr. Dan Huang

Research lab led by Connie Hsia, M.D., in the Biomedical Engineering Graduate Program of UT Southwestern Medical School.

Radiology lab led by Dr. Paulo Eduardo de Aguiar Kuriki

The goal of the Choi Lab is to develop novel immunotherapies. To accomplish this, we first utilize high-dimensional approaches on human disease samples. This approach identifies targetable disease-promoting molecular defects in immune cells. Then, we utilize engineering approaches ot reverse the molecular changes. 

Dr. Noh's research specializes in deducing causal inference for time series microscopy images and developing statistical methods for genomic data analysis. Currently, he collaborates with peers in the Green Center for Systems Biology and in the Lyda Hill Department of Bioinformatics to develop statistical methods to resolve complex biomedical data.

research lab at UT Southwestern for Yun Wei, Ph.D.

Our research focuses on developing and translating computational neuroimaging methods to delineate human brain structure-function relationships. Current applications include identifying biomarkers of disease progression and treatment response in multiple sclerosis and other neurodegenerative diseases. 

Dr. Li's research focuses on gene-environment interactions in cardiometabolic disease and chronic kidney disease (CKD), providing crucial insights for precision health. 

Muto lab leverages both cutting-edge wet-lab and multi-omics approaches to understand gene regulatory mechanism driving kidney diseases. Current projects are focused on acute kidney injury and polycystic kidney disease.

The Gloeggler lab is interested in spin phenomena and explores how to use them as new contrast mechanism for magnetic resonance. One focus is on using parahydrogen, a spin isomer of hydrogen gas, and how to harvest its spin order to obtain signal enhanced/hyperpolarized contrast agents. 

Our current research is focused on biochemical and structural studies of how membrane molecules signal to the actin cytoskeleton through a large, five-protein complex named the WAVE Regulatory Complex (WRC). 

We investigate the neuroepigenetic mechanisms regulating synaptic plasticity in the hypothalamus, their role in maintaining body weight set-point, and how their dysregulation contributes to diet-induced obesity, weight-regain, and aging-related impairments in appetite.

Dr. Kang's research is dedicated to elucidating the molecular and immunological roles of damage-associated molecular patterns (DAMPs) and pattern recognition receptors (PRRs) in inflammatory diseases.