Research Interests
Develop bioinspired matrices for mineralized tissue regeneration
Nanofibrous matrix mimics the hard tissue matrices and presents unique biophysical cues to facilitate osteogenic/odontogenic responses of mesenchymal cells. The high surface area of the nanofibrous scaffolds also results in a high drug loading, especially for bioactive proteins. Therefore, the nanofibrous architecture is considered as an indispensable feature for establishing new generation scaffolds for hard tissue engineering. Our goal is to develop 3D preformed or injectable scaffolding systems with nanofibrous matrix for hard tissue regeneration.
Develop animal models and test advanced tissue engineering strategies for bone tissue regeneration
A reliable animal model is foundational for the development of novel therapeutic strategies for skeletal diseases. Large animal models for testing multiple variables have been limited due to the cost. The study aims to develop effective rat models and to test biomaterial-based treatments for challenged skeletal diseases, such as osteonecrosis, osteoarthritis, and critical-sized bone defects.
