Ren Lab Publications | SRC Center for Translational Research at UTSW

Local BMP2 hydrogel therapy for robust bone regeneration in a porcine model of Legg-Calvé-Perthes disease.

Ma C, Park MS, Alves do Monte F, Gokani V, Aruwajoye OO, Ren Y, Liu X, Kim HKW, 2023 Sep NPJ Regen Med 1 8 50

Aged G Protein-Coupled Receptor Kinase 3 (Grk3)-Deficient Mice Exhibit Enhanced Osteoclastogenesis and Develop Bone Lesions Analogous to Human Paget's Disease of Bone.

Rabjohns EM, Rampersad RR, Ghosh A, Hurst K, Eudy AM, Brozowski JM, Lee HH, Ren Y, Mirando A, Gladman J, Bowser JL, Berg K, Wani S, Ralston SH, Hilton MJ, Tarrant TK, 2023 Mar Cells 7 12

Glutathione limits RUNX2 oxidation and degradation to regulate bone formation.

Hu G, Yu Y, Sharma D, Pruett-Miller SM, Ren Y, Zhang GF, Karner CM, 2023 Jul JCI Insight

Local Administration of Bone Morphogenetic Protein-2 Using a Hydrogel Carrier for Robust Bone Regeneration in a Large Animal Model of Legg-Calvé-Perthes disease.

Kim H, Ma C, Park M, Monte F, Gokani V, Aruwajoye O, Ren Y, Liu X, 2023 Jan Res Sq

Interleukin-6 signaling mediates cartilage degradation and pain in posttraumatic osteoarthritis in a sex-specific manner.

Liao Y, Ren Y, Luo X, Mirando AJ, Long JT, Leinroth A, Ji RR, Hilton MJ, 2022 Jul Sci Signal 744 15 eabn7082

G protein-coupled receptor kinase 3 modulates mesenchymal stem cell proliferation and differentiation through sphingosine-1-phosphate receptor regulation.

Brozowski JM, Timoshchenko RG, Serafin DS, Allyn B, Koontz J, Rabjohns EM, Rampersad RR, Ren Y, Eudy AM, Harris TF, Abraham D, Mattox D, Rubin CT, Hilton MJ, Rubin J, Allbritton NL, Billard MJ, Tarrant TK, 2022 Jan Stem Cell Res Ther 1 13 37

Hypertrophic chondrocytes serve as a reservoir for marrow associated skeletal stem and progenitor cells, osteoblasts, and adipocytes during skeletal development.

Long JT, Leinroth A, Liao Y, Ren Y, Mirando AJ, Nguyen T, Guo W, Sharma D, Rouse D, Wu C, Cheah KSE, Karner CM, Hilton MJ, 2022 Feb Elife 11

Damage Associated Molecular Patterns in Necrotic Femoral Head Inhibit Osteogenesis and Promote Fibrogenesis of Mesenchymal Stem Cells.

Deng Z, Ren Y, Park MS, Kim HKW, 2021 Sep Bone 116215

Minimally Invasive Necrotic Bone Washing Improves Bone Healing After Femoral Head Ischemic Osteonecrosis: An Experimental Investigation in Immature Pigs.

Kim HKW, Park MS, Alves do Monte F, Gokani V, Aruwajoye OO, Ren Y, 2021 Mar J Bone Joint Surg Am

Development of a murine model of ischemic osteonecrosis to study the effects of aging on bone repair.

Yamaguchi R, Kamiya N, Kuroyanagi G, Ren Y, Kim HKW, 2021 Dec J Orthop Res 12 39 2663-2670

Anti-Interleukin-6 Therapy Decreases Hip Synovitis and Bone Resorption and Increases Bone Formation Following Ischemic Osteonecrosis of the Femoral Head.

Ren Y, Deng Z, Gokani V, Kutschke M, Mitchell TW, Aruwajoye O, Adapala NS, Kamiya N, Abu-Amer Y, Kim HK, 2021 02 J Bone Miner Res 2 36 357-368

Osteocytes but not osteoblasts directly build mineralized bone structures.

Wang K, Ren Y, Lin S, Jing Y, Ma C, Wang J, Yuan XB, Han X, Zhao H, Wang Z, Zheng M, Xiao Y, Chen L, Olsen BR, Feng JQ, 2021 Int J Biol Sci 10 17 2430-2448

The CaV1.2 L-type calcium channel regulates bone homeostasis in the middle and inner ear.

Cao C, Oswald AB, Fabella BA, Ren Y, Rodriguiz R, Trainor G, Greenblatt MB, Hilton MJ, Pitt GS, 2019 Aug Bone 125 160-168

Interleukin-6 deletion stimulates revascularization and new bone formation following ischemic osteonecrosis in a murine model.

Kuroyanagi G, Adapala NS, Yamaguchi R, Kamiya N, Deng Z, Aruwajoye O, Kutschke M, Chen E, Jo C, Ren Y, Kim HKW 2018 Aug Bone 116 221-231

Increased Ca2+ signaling through CaV1.2 promotes bone formation and prevents estrogen deficiency-induced bone loss.

Cao C, Ren Y, Barnett AS, Mirando AJ, Rouse D, Mun SH, Park-Min KH, McNulty AL, Guilak F, Karner CM, Hilton MJ, Pitt GS 2017 Nov JCI Insight 22 2

BMP1 and TLL1 Are Required for Maintaining Periodontal Homeostasis.

Wang J, Massoudi D, Ren Y, Muir AM, Harris SE, Greenspan DS, Feng JQ 2017 May J. Dent. Res. 5 96 578-585

Essential Roles of Bone Morphogenetic Protein-1 and Mammalian Tolloid-like 1 in Postnatal Root Dentin Formation.

Wang J, Muir AM, Ren Y, Massoudi D, Greenspan DS, Feng JQ 2017 Jan J Endod 1 43 109-115

Sclerostin Antibody Preserves the Morphology and Structure of Osteocytes and Blocks the Severe Skeletal Deterioration After Motor-Complete Spinal Cord Injury in Rats.

Qin W, Li X, Peng Y, Harlow LM, Ren Y, Wu Y, Li J, Qin Y, Sun J, Zheng S, Brown T, Feng JQ, Ke HZ, Bauman WA, Cardozo CP 2016 Jul J. Bone Miner. Res. 7 31 1482

Expression of the invertebrate sea urchin P16 protein into mammalian MC3T3 osteoblasts transforms and reprograms them into "osteocyte-like" cells.

Alvares K, Ren Y, Feng JQ, Veis A 2016 Jan J. Exp. Zool. B Mol. Dev. Evol. 1 326 38-46

Critical roles of periostin in the process of orthodontic tooth movement.

Rangiani A, Jing Y, Ren Y, Yadav S, Taylor R, Feng JQ 2016 Aug Eur J Orthod 4 38 373-8

NOTCH signaling in skeletal progenitors is critical for fracture repair.

Wang C, Inzana JA, Mirando AJ, Ren Y, Liu Z, Shen J, O'Keefe RJ, Awad HA, Hilton MJ 2016 Apr J. Clin. Invest. 4 126 1471-1481

HES factors regulate specific aspects of chondrogenesis and chondrocyte hypertrophy during cartilage development.

Rutkowski TP, Kohn A, Sharma D, Ren Y, Mirando AJ, Hilton MJ 2016 06 J. Cell. Sci. 11 129 2145-55

Notch signaling in postnatal joint chondrocytes, but not subchondral osteoblasts, is required for articular cartilage and joint maintenance.

Liu Z, Ren Y, Mirando AJ, Wang C, Zuscik MJ, O'Keefe RJ, Hilton MJ 2015 Oct Osteoarthr. Cartil.

Sclerostin antibody preserves the morphology and structure of osteocytes and blocks the severe skeletal deterioration after motor-complete spinal cord injury in rats.

Qin W, Li X, Peng Y, Harlow LM, Ren Y, Wu Y, Li J, Qin Y, Sun J, Zheng S, Brown T, Feng JQ, Ke HZ, Bauman WA, Cardozo CC 2015 May J. Bone Miner. Res.

Removal of SOST or blocking its product sclerostin rescues defects in the periodontitis mouse model.

Ren Y, Han X, Ho SP, Harris SE, Cao Z, Economides AN, Qin C, Ke H, Liu M, Feng JQ 2015 Mar FASEB J.

Sclerostin antibody (Scl-Ab) improves osteomalacia phenotype in dentin matrix protein 1(Dmp1) knockout mice with little impact on serum levels of phosphorus and FGF23.

Ren Y, Han X, Jing Y, Yuan B, Ke H, Liu M, Feng JQ 2015 Dec Matrix Biol.

Complete pulpodentin complex regeneration by modulating the stiffness of biomimetic matrix.

Qu T, Jing J, Ren Y, Ma C, Feng JQ, Yu Q, Liu X 2015 Apr Acta Biomater 16 60-70

Induced ablation of Bmp1 and Tll1 produces osteogenesis imperfecta in mice.

Muir AM, Ren Y, Butz DH, Davis NA, Blank RD, Birk DE, Lee SJ, Rowe D, Feng JQ, Greenspan DS 2014 Jun Hum. Mol. Genet. 12 23 3085-101

A novel way to statistically analyze morphologic changes in Dmp1-null osteocytes.

Ren Y, Lin S, Jing Y, Dechow PC, Feng JQ 2014 Aug Connect. Tissue Res. 55 Suppl 1 129-33

BMP receptor 1A determines the cell fate of the postnatal growth plate.

Jing J, Ren Y, Zong Z, Liu C, Kamiya N, Mishina Y, Liu Y, Zhou X, Feng JQ 2013 Int. J. Biol. Sci. 9 9 895-906

Genetic evidence for the vital function of Osterix in cementogenesis.

Cao Z, Zhang H, Zhou X, Han X, Ren Y, Gao T, Xiao Y, de Crombrugghe B, Somerman MJ, Feng JQ 2012 May J. Bone Miner. Res. 5 27 1080-92

Post-natal effect of overexpressed DKK1 on mandibular molar formation.

Han XL, Liu M, Voisey A, Ren YS, Kurimoto P, Gao T, Tefera L, Dechow P, Ke HZ, Feng JQ 2011 Nov J. Dent. Res. 11 90 1312-7

Inhibition of phosphatidylcholine-specific phospholipase C prevents bone marrow stromal cell senescence in vitro.

Sun C, Wang N, Huang J, Xin J, Peng F, Ren Y, Zhang S, Miao J 2009 Oct J. Cell. Biochem. 2 108 519-28