How do cells sense metabolites to drive their growth and proliferation?  We seek to study metabolites not only as nutrients but as cellular instruction signals that dictate cell biology. 

The Tu Lab is investigating how a variety of cellular processes and decisions are coordinated with metabolic state, and how the dysregulation of these mechanisms might be linked to disease and aging.

Our primary goal in Sieber Lab is to understand the dynamic changes in metabolic programs that support developmental and disease progression. 

The general focus of the Green Lab is to understand the molecular mechanism of the mammalian circadian clock, how it controls rhythmic biochemistry, physiology and behavior and how loss of clock function can impact health, resulting in metabolic disease, cancer and other ailments.

The Douglas lab seeks to understand how stress response pathways alter cell physiology, and ultimately influence the aging process and human disease.

Our research focuses on how the conserved signaling pathways that underlie normal skin development are altered during the development of non-melanoma skin cancers and inflammatory skin disease.

The Mangelsdorf/Kliewer Lab studies two signal transduction pathways that offer new therapeutic potential for treating diseases such as diabetes, obesity, cancer, and parasitism.

The primary research focus of the Karner lab is to create and utilize novel mouse genetic models to study the role of cellular metabolism during skeletal development and disease. 

The Luo lab studies hypoxia stress in human cancers with a focus on epigenetic and metabolic alterations. 

Research in the Rothermel Laboratory focuses on deciphering the molecular mechanisms that control cardiac structure and function during normal development and in response to pathological stress.