The Liang lab's research focuses on delineating the pathophysiological mechanisms underlying chronic liver disease.

Our lab is studying novel regulatory mechanisms that control innate immunity in intestinal health and disease.

We aim to elucidate the role of the innate immune system in damage and repair following ischemic and hemorrhagic insults to the brain. We are specifically focused on innate immune drivers of secondary injury following aneurysmal subarachnoid hemorrhage and the immune response triggered by acute intracranial pressure spikes during aneurysm rupture. We also look into promoting recovery after ischemic stroke by reprogramming microglia and peripheral myeloid cells to drive repair. In addition, we are pursuing the development of therapeutics for intraarterial immunomodulation for chronic subdural hemorrhage.

The Farrar Lab is interested in understanding how external signals regulate immune cell function and development. 

Our lab studies the fundamental mechanisms of how commensal fungi survive and persist within a host niche filled with a multitude of innate and adaptive immune effectors, under both homeostatic and inflammatory conditions. We aim for our study to provide unique insights into human diseases, such as asthma, inflammatory bowel disease, and cancer, and provides the foundation for novel immunotherapeutic approaches.

The Yue lab focuses on developing translational immunology platforms to uncover the molecular and cellular mechanisms underlying immunotherapy resistance and to design next-generation cancer immunotherapies.

The Monson Lab is dedicated to understanding how B cells and T cells impact pathology of disease in the central nervous system.

The research of the Huang Laboratory focuses on understanding the function of fibroblast progenitor cells and fibroblasts in regulating the immune system.

The focus of the Obata Lab is to study how environmental signals (e.g., microbiota, diet, day/night cycles) shape intestinal neural circuits and immune cell networks. A variety of experimental techniques are used, including state-of-the-art imaging technologies, viral tracing of gut innervation, in vivo and ex vivo physiological assays, gnotobiotic systems and multi-omics technologies. The Obata Lab is also interested in elucidating the molecular mechanisms of inter-organ communication, including the Gut-Brain axis.

In our lab, we investigate the interactions between these multiple pathogens and the immune system.