We are broadly interested in understanding how resident intestinal bacteria influence the biology of humans and other mammalian hosts.

We combine classical genetics with modern technology to understand human physiology and search for breakthrough treatments for diseases.

The Reinecker laboratory unravels and targets molecular mechanisms of key human genetic variants that cause chronic inflammatory diseases and cancer by creating novel genetic mouse and human organotypic model systems.

Zhong Lab studies studies inflammation, mitochondrial stress responses, tumor immunology and obesity-associated liver disorders.  

Yao Laboratory identifies molecular and cellular mechanisms that determine the efficacy of vaccines and immunotherapies against infectious diseases and cancers.

The Turer Lab is interested in finding genes with novel functions in intestinal immune homeostasis. Our projects generally involve a mix of experimental approaches examining both the intestinal epithelium as well as hematopoietic causes of intestinal inflammation.

The Wakeland Lab utilizes state-of-the-art genomic strategies to investigate the diversity of the human and mouse immune systems. 

Satterthwaite Lab studies the signals that control B lymphocyte development, activation, and differentiation into antibody-secreting plasma cells, both normally and in autoimmune diseases such as lupus. We hope that by defining these events, we can reveal new approaches to modulate antibody responses therapeutically.

The Wu Lab focuses on understanding the molecular pathways that govern T cell differentiation and function during infection and cancer.

Orchard Lab at UT Southwestern Medical Center