Satterthwaite Lab studies the signals that control B lymphocyte development, activation, and differentiation into antibody-secreting plasma cells, both normally and in autoimmune diseases such as lupus. We hope that by defining these events, we can reveal new approaches to modulate antibody responses therapeutically.

The Wu Lab focuses on understanding the molecular pathways that govern T cell differentiation and function during infection and cancer.

Orchard Lab at UT Southwestern Medical Center

The Sandstrom Lab works to identify the fundamental molecular mechanisms through which the immune system can recognize pathogens and stress. 

For decades, the field of tuberculosis (TB) immunology has focused on T cell mediated protection, yet Mycobacterium tuberculosis (Mtb) still impacts one in four individuals worldwide today.

Bridging immunology, microbiology, and metabolism, the Harris-Tryon Lab at UT Southwestern develops novel therapeutic targets for inflammatory skin condtions.

Our goal is to understand and exploit the immunogenic properties of tumor irradiation in integrating it with immunotherapy to improve cancer patient outcome.

We employ a variety of methods including evolutionary analysis, genomics, and molecular biology to study the biology of infection.

The Yan Lab studies molecular mechanisms of innate immunity in infection, autoimmune diseases, cancer immunology and neurodegenative diseases.

Children with in-born errors of immunity are prone to life-threatening viral, bacterial, and fungal infections. We study the causes of their immune system problems, combining clinical insights and mouse models genocopying the various mutations. This work includes a profiling of immune responses to infections (e.g., COVID-19) in normal healthy individuals along with different patient populations (e.g. 22q11.2 deletion syndrome).