The Tambar Group develops new strategies and concepts in synthetic chemistry to address challenging problems in chemistry and biology.

The overarching goals of our lab are to understand the posttranscriptional mechanisms of gene expression and regulation in the Kaposi's sarcoma-associated herpesvirus (KSHV) and its human host cell. We are particularly focused on the mechanisms and regulation of nuclear RNA stability, polyadenylation, and mRNA processing by viral and by host cell factors.

Our lab works with murine disease models and employs Biochemistry, Molecular and Cell Biology to investigate brain glycogen metabolism and related neurodegenerative diseases.

We focus on the discovery of targeted therapies for major drivers of cancer using protein chemistry, enzymology, structural biology, informatics and cell biology. Some of our favorite targets are RAS and kinase proteins.

D'Orso Lab studies gene regulatory networks in normal and disease states as well as in the context of host-pathogen interactions.

We are developing inhibitors of pyrimidine biosynthesis and polyamine biosynthesis to treat malaria and African sleeping sickness. We study polyamine and nucleotide metabolism in African trypanosomes to learn about novel metabolism and regulation.

Corey Lab is using nucleic acids or nucleic acid mimics to explore important cellular processes, develop novel therapeutic tools and strategies.

The Kohler research group is committed to developing and implementing new tools optimized for the study of glycosylated molecules.