The McFadden lab uses genetically engineered mice and human cancer cells to identify new genes and small molecules that regulate cancer cell growth.

Our research focuses on how the conserved signaling pathways that underlie normal skin development are altered during the development of non-melanoma skin cancers and inflammatory skin disease.

The broad research interest of Fei Wang lab is in dissecting molecular mechanisms of essential membrane-associated cellular events in eukaryotic cell development.

The Orth lab is interested in elucidation the activity of virulence factors from pathogenic bacteria so that we can gain novel molecular insight into eukaryotic signaling systems.

Our laboratory is interested in investigating the molecular mechanisms of selenoproteins in health and disease.

The Luo lab studies hypoxia stress in human cancers with a focus on epigenetic and metabolic alterations. 

We are interested in how membrane cholesterol controls diverse cellular signaling pathways to ensure lipid homeostasis, enable cell growth, and protect against infections. 

The Tambar Group develops new strategies and concepts in synthetic chemistry to address challenging problems in chemistry and biology.

The overarching goals of our lab are to understand the posttranscriptional mechanisms of gene expression and regulation in the Kaposi's sarcoma-associated herpesvirus (KSHV) and its human host cell. We are particularly focused on the mechanisms and regulation of nuclear RNA stability, polyadenylation, and mRNA processing by viral and by host cell factors.

Our lab works with murine disease models and employs Biochemistry, Molecular and Cell Biology to investigate brain glycogen metabolism and related neurodegenerative diseases.