The significance of our research is to show effective anti-Aβ42 antibody production in large animals and safety of DNA Aβ42 immunotherapy in these models to proceed with vaccination in patients at risk for Alzheimer’s disease.
Our lab is using various approaches to explore this biology and develop new treatments with a focus on targeting tumor intrinsic factors such as genetic programs like the epithelial to mesenchymal transition that coordinate with infiltrating immune cells in enhance therapeutic resistance and assist distant spread.
Satterthwaite Lab studies the signals that control B lymphocyte development, activation, and differentiation into antibody-secreting plasma cells, both normally and in autoimmune diseases such as lupus. We hope that by defining these events, we can reveal new approaches to modulate antibody responses therapeutically.
The Wu Lab focuses on understanding the molecular pathways that govern T cell differentiation and function during infection and cancer.
Orchard Lab at UT Southwestern Medical Center
The Sandstrom Lab works to identify the fundamental molecular mechanisms through which the immune system can recognize pathogens and stress.
For decades, the field of tuberculosis (TB) immunology has focused on T cell mediated protection, yet Mycobacterium tuberculosis (Mtb) still impacts one in four individuals worldwide today.
The Schoggins Lab studies innate immunity at the virus-host interface. We are interested in mechanisms of cellular antiviral defense and the role these responses play during viral disease.
Our focus is on gaining a greater understanding of how bacteria on the skin surface affect skin health and diseases.
We employ a variety of methods including evolutionary analysis, genomics, and molecular biology to study the biology of infection.
