The Yan Lab studies molecular mechanisms of innate immunity in infection, autoimmune diseases, cancer immunology and neurodegenative diseases.

Children with in-born errors of immunity are prone to life-threatening viral, bacterial, and fungal infections. We study the causes of their immune system problems, combining clinical insights and mouse models genocopying the various mutations. This work includes a profiling of immune responses to infections (e.g., COVID-19) in normal healthy individuals along with different patient populations (e.g. 22q11.2 deletion syndrome).

The goal of our research is to identify key immune checkpoints of gastrointestinal disorders that could be targeted for therapeutic intervention and drug development.

The ultimate aim of the Shiloh Lab is to contribute to the development of vaccines and treatments for Mycobacterium tuberculosis (Mtb).

The lab's long-term goal is to illuminate the function of immune surface molecules and to open up a new research field at the interface of cancer, immunology, and stem cell research. Zhang Lab also actively develops novel therapies for cancer treatment.

Burstein Laboratory focuses on understanding the regulation of the inflammatory response at a molecular level, and elucidating how these events may participate in human disease.