We study ion channel clusters. To study such clusters without the complications arising from the complex cellular environment, components from cells are purified and studied in isolation.

The Luo lab studies the molecular mechanisms of intracellular signal transduction, focusing on the spindle checkpoint and the Hippo tumor-suppressor pathway.

The Shahmoradian lab investigates the roles of domain-specific neuronal proteins using advanced cryo-imaging techniques to understand their impact on cellular dynamics and neurological health.

The Lin lab develops theoretical models and uses computational tools to find the performance limits of complex biological systems. 

Xin Liu Lab is interested in understanding the regulation of transcription and chromatin dynamics underlying many fundamental biological processes including differentiation, development, and oncogenesis.

Goldsmith Lab combines drug discovery and mechanistic analysis to understanding protein kinases. 

Henne lab is interested in how cells spatially organize their metabolism to adapt to a constantly changing environment.

This facility is the home to five high field solution NMR spectrometers ranging from 500 MHz to 800 MHz and a Solid State 600 MHz DNP system, primarily in support of studies of macromolecular structure, function and dynamics.

We are a group of physicists, biophysicists, cell biologists, and “computationalists” interested in the spatiotemporal organization of cell surface receptors, the mechanisms underlying it, and its consequences for cell signaling. We utilize light microscopy, particularly single-molecule and super-resolution imaging, to monitor molecular behavior in its native cellular environment, and we develop computer vision and machine learning approaches to quantitate the observed behavior and gain insight beyond what the eye can see.

Jan’s Lab is interested in understanding the dynamics of protein-RNA complexes during ribosome biogenesis. We are particularly focused on the roles of ATPases in coordinating ribosomal RNA processing and remodeling events, as well as the importance of these enzymes in signaling between the ribosome biogenesis pathway and the cell cycle machinery.