We use live-cell microscopy, nano-rheology, and synthetic biology to understand oocyte ageing, embryogenesis, and cancer onset.

Jan’s Lab is interested in understanding the dynamics of protein-RNA complexes during ribosome biogenesis. We are particularly focused on the roles of ATPases in coordinating ribosomal RNA processing and remodeling events, as well as the importance of these enzymes in signaling between the ribosome biogenesis pathway and the cell cycle machinery.

The Zhang Lab studies intra- and inter-molecular interactions to understand how signaling proteins are regulated, using biochemistry, X-ray crystallography, cryo-EM and cell biology.

Saelices Lab employs crystallography and cryo-EM to study amyloid deposition and design anti-amyloid tools.

The Rosen Lab seeks to understand the formation, regulation, functions and internal structures of membraneless cellular compartments termed biomolecular condensates.