The Marciano laboratory investigates fundamental aspects of kidney development and regeneration, in both health and disease.

We study bacterial colonization of the intestinal tract, to understand how both benign and pathological bacteria affect their environment. Our long-term goal is to treat intestinal diseases by genetically engineering bacteria in vivo.

The James Kim Lab examines the communication between epithelia and stroma through the lens of fundamental developmental pathways such as Hedgehog, Wnt, and Notch pathways.

Our team at UT Southwestern is conducting the study Improving Chronic Disease Management with Pieces (IDC-Pieces) in patients with coexistent chronic kidney disease, diabetes and hypertension.

The Reinecker laboratory unravels and targets molecular mechanisms of key human genetic variants that cause chronic inflammatory diseases and cancer by creating novel genetic mouse and human organotypic model systems.

My research interests include prevention of progression of renal diseases, diagnoses, and management of lipid disorders in renal disease, hypertensive nephrosclerosis, the role of angiotensin II converting enzyme inhibitors, and angiotensin II receptor blockers in renal disease. 

The Saxena lab's research interests include Icodextin in high peritoneal transporters; Kremezin study in patients with chronic kidney disease; SV40 in focal segmental glomerulosclerosis; molecular studies in lupus nephritis.

Dr. Vongpatanasin studies neural control of blood pressure and the influence of various hormones and antihypertensive agents on autonomic control of blood pressure in humans. 

We use in vivo models of ischemic acute kidney injury in mice, and in vitro model systems to perform detailed studies of proinflammatory genes activated by renal ischemia/reperfusion.

Our laboratory is focused on the molecular control of lipid metabolism, particularly in the intestinal tract. We employ a variety of disciplines including molecular and cell biology, mouse models and organoid technologies.