The autonomic nervous system comprises a network of sensory and motor neurons that connect the brainstem and spinal cord to thoracic and abdominal organs. A better understanding of the anatomical and functional plasticity of the autonomic nervous system will likely move forward our understanding of numerous chronic diseases including, but not limited to, obesity, diabetes, visceral pain, neuropathy, and eating disorders.
Obesity and metabolic diseases have been increasing at the alarming rate and threatening our health and economy over the world. However, we still don’t know much about how our metabolic homeostasis is regulated. Understanding the mechanism underlying the regulation of metabolism is a fundamental step towards designing new treatments for obesity and its associated diseases, and many other metabolic diseases
The Elmquist laboratory uses mouse genetics to identify circuits in the nervous system that regulate energy balance and glucose homeostasis. We have developed unique mouse models allowing neuron-specific manipulation of genes regulating these processes.
Our lab is creating better experimental models that reveal how cancer cells metastasize and evade our immune system. We use these models to develop new drugs that engage our immune system to kill cancer cells.
We strive to decipher mechanisms of structural, functional, and electrical remodeling in heart disease with an eye toward therapeutic intervention.
Dr. Bedimo studies strategies for optimally managing drug-resistant HIV patients, analyzing metabolic abnormalities in HIV patients, and studying the effects of HCV co-infection.
We combine classical genetics with modern technology to understand human physiology and search for breakthrough treatments for diseases.
The Rohatgi Lab focuses on the role of reverse cholesterol transport in atheroprotection.
Dr. Garg's research focuses on diabetes, insulin resistance, and disorders of adipose tissue.
