Yu Lab is interested in the molecular and cellular basis of Alzheimer’s disease, amyotrophic lateral sclerosis, frontotemporal dementia, and related neurodegenerative disorders.

The Wetzel Lab targets critical steps in the parasite’s life cycle in order to develop therapeutics for Leishmaniasis.

The general focus of the Green Lab is to understand the molecular mechanism of the mammalian circadian clock, how it controls rhythmic biochemistry, physiology and behavior and how loss of clock function can impact health, resulting in metabolic disease, cancer and other ailments.

The Turer Lab is interested in finding genes with novel functions in intestinal immune homeostasis. Our projects generally involve a mix of experimental approaches examining both the intestinal epithelium as well as hematopoietic causes of intestinal inflammation.

We study how the membrane lipid phosphatidylinositol 4,5 bisphosphate (PIP2) regulates the actin scaffold in proliferating and autophagic cells.

The Cobb lab studies signal transduction mechanisms of protein kinases and how kinase structures lead to cell biological functions. We are particularly focused on the contributions of ERK MAP kinases to pancreatic beta-cell function and to lung cancers, and on the cell biological actions of WNK protein kinases.

Malter Lab focuses on exploring and characterizing intracellular signaling pathways in the immune and nervous systems and identifying how defects/abnormalities can lead to disease.

Our lab focuses on membrane proteins in cholesterol biogenesis, transport, and signaling using multiple approaches from protein engineering, to x-ray crystallography and cryo-EM.

Our research is focused on mechanisms underlying acute kidney injury and sepsis.  Our laboratory has implicated mitochondrial maintenance via PGC1alpha and NAD+ as a novel pathway for resilience against acute physiological stressors.

The Douglas lab seeks to understand how stress response pathways alter cell physiology, and ultimately influence the aging process and human disease.