In the Zhang Lab, we seek to understand the molecular mechanisms of metabolic diseases, with the long-term goal of creating novel therapeutic strategies.

The Pan laboratory uses Drosophila and mice as model systems to investigate size-control mechanisms in normal development and their pathological roles in cancer.

O'Donnell Lab investigates mechanisms of tumor initiation, progression, and metastasis using molecular and biochemical studies and animal models.

The Tagliabracci Lab studies the phosphorylation of extracellular proteins by a novel family of secreted kinases. This kinase family is so different from canonical kinases that it was not included as a branch on the human kinome tree.

The main goals of the Strand Lab are to create accurate cellular atlases of the human and mouse lower urinary tract, characterize the molecular and cellular alterations in human lower urinary tract disease, and design new mouse models.

The Jiang lab studies fundamental mechanisms governing how diverse cell types are generated from naive progenitor cells and how cells of different types are put together to form appropriate body structures such as limbs during embryonic development. The lab also studies how damaged cells are replenished by stem cells during tissue repair and organ regeneration in adult life. We are particularly interested in understanding how cells communicate with one another to influence their growth and fate determination and how miscommunication among different cells leads to developmental abnormality and cancer progression.

The Mendell laboratory investigates fundamental aspects of post-transcriptional gene regulation, noncoding RNA regulation and function, and the roles of these pathways in normal physiology, cancer, and other diseases.

The Dellinger Laboratory studies the development of the lymphatic vasculature and diseases caused by errors in the development of lymphatic vessels.

Buszczak laboratory seeks to gain new insights into mRNA translation, ribosome biogenesis and germ cell biology 

The primary research focus of the Karner lab is to create and utilize novel mouse genetic models to study the role of cellular metabolism during skeletal development and disease.