The Jiang lab studies fundamental mechanisms governing how diverse cell types are generated from naive progenitor cells and how cells of different types are put together to form appropriate body structures such as limbs during embryonic development. The lab also studies how damaged cells are replenished by stem cells during tissue repair and organ regeneration in adult life. We are particularly interested in understanding how cells communicate with one another to influence their growth and fate determination and how miscommunication among different cells leads to developmental abnormality and cancer progression.

The Mendell laboratory investigates fundamental aspects of post-transcriptional gene regulation, noncoding RNA regulation and function, and the roles of these pathways in normal physiology, cancer, and other diseases.

The Dellinger Laboratory studies the development of the lymphatic vasculature and diseases caused by errors in the development of lymphatic vessels.

Buszczak laboratory seeks to gain new insights into mRNA translation, ribosome biogenesis and germ cell biology 

The primary research focus of the Karner lab is to create and utilize novel mouse genetic models to study the role of cellular metabolism during skeletal development and disease. 

Dr. Gray is overseeing one of the nation’s few facilities that manufactures a special type of gene-delivering virus for patient use.

We use genetic systems to deconstruct functions associated with the most commonly mutated genes found in human cancers.

Located in the Department of Ophthalmology, the Wert laboratory studies the post-mitotic neuronal cells of the retina, particularly the photoreceptor cells. Our goal is to discover and understand the mechanisms underlying retinal degenerative disease, and to provide novel therapeutics for these complex degenerative disorders using gene therapy and genome engineering technologies, human stem cell transplantations, and metabolic rescue.

We employ a variety of methods including evolutionary analysis, genomics, and molecular biology to study the biology of infection.

The overall goal of our laboratory is to discover the processes in endothelial cells that govern cardiovascular and metabolic health and disease.