Mootha Lab uses human genetics and genomics to understand the molecular basis of Fuchs' endothelial corneal dystrophy and develop novel therapeutic strategies.

The overall focus of the Ram Mani Lab is to study the molecular genetic and epigenetic events associated with cancer development.

Interrogating the genome to better understand the mechanisms causing autism spectrum disorder and other neurodevelopmental disorders and inform innovative therapies

The Douglas lab seeks to understand how stress response pathways alter cell physiology, and ultimately influence the aging process and human disease.

Mukhopadhyay Lab research aims to understand how the primary cilium regulates downstream pathways to ultimately drive morphogenesis in different tissues. We undertake a multi-pronged approach including proteomics, cell biology, biochemistry, reverse genetics, and generation of innovative mouse models to study regulation of signaling pathways by cilia in in cellular and organismal contexts.

The Kraus Lab is interested in the basic mechanisms of nuclear signaling and gene regulation by small molecules and how these signaling pathways relate to human physiology and disease states.

The major interest of my lab is to understand the transcriptional regulatory mechanisms involved in human diseases with a focus on cardiovascular diseases and cancer. 

The Wang Lab studies neurodegeneration and cell death induced by brain injury, mitochondrial dysfunction, and/or genome instability.

The Wu Laboratory mainly focuses on using stem cell models to gain novel insights in mammalian development and develop regenerative medical applications.

Our research program focuses on understanding how dysregulation of lipid uptake and trafficking contributes to human diseases.