We aim to elucidate the role of the innate immune system in damage and repair following ischemic and hemorrhagic insults to the brain. We are specifically focused on innate immune drivers of secondary injury following aneurysmal subarachnoid hemorrhage and the immune response triggered by acute intracranial pressure spikes during aneurysm rupture. We also look into promoting recovery after ischemic stroke by reprogramming microglia and peripheral myeloid cells to drive repair. In addition, we are pursuing the development of therapeutics for intraarterial immunomodulation for chronic subdural hemorrhage.

The Thinwa lab studies neurotropic viruses, host defense pathways, autophagy and brain development.

The Farrar Lab is interested in understanding how external signals regulate immune cell function and development. 

The Nair-Gill Lab dissects the cellular infrastructure that dictates immune cell survival and fate decisions.

The research of the Huang Laboratory focuses on understanding the function of fibroblast progenitor cells and fibroblasts in regulating the immune system.

Our focus is on gaining a greater understanding of how bacteria on the skin surface affect skin health and diseases.

Children with in-born errors of immunity are prone to life-threatening viral, bacterial, and fungal infections. We study the causes of their immune system problems, combining clinical insights and mouse models genocopying the various mutations. This work includes a profiling of immune responses to infections (e.g., COVID-19) in normal healthy individuals along with different patient populations (e.g. 22q11.2 deletion syndrome).

Sumber Lab conducts translational research that seeks to uncover the mysteries of cancer and develop powerful methods for its detection and cure.