We are interested in basic cellular and molecular mechanisms driving early blood vessel formation. We aim to study this process in the developing embryo, as well as in engineered and regenerating tissues.
Dr. Cleaver joined UT Southwestern’s Molecular Biology as faculty in late 2004 and was promoted to Associate Professor in 2010.
Her lab studies cell fate and how cells assemble into tissues. Her group is particularly interested in intracellular signaling events that drive cytoskeletal or adhesion changes within progenitor cells, allowing them to assemble into functional tissues. She focuses on blood vessels and on developing organs, such as the pancreas, the kidney, and the lung. She is interested in how cues in the microenvironment drive vascular assembly or growth, and how blood vessels in turn communicate paracrine, non-nutritional signals to stem cell niches.