One of our research goals is to understand the growing blood vessels within developing organs. We want to know:
- How do tissues direct blood vessel patterning via angiogenic factors?
- How does the endothelium, in turn, influence embryonic cell differentiation?
We hypothesize that reciprocal signals underlie the coordinated growth of blood vessels and the morphogenesis of organs and that mutual signaling forms the basis for interdependent physiological relationships that last into adulthood.
Understanding this endothelium-tissue crosstalk will be the focus of our research.