The Cleaver Lab is interested in the molecular mechanisms of cell fate specification during blood vessel development and organogenesis.
By using the mouse as a model system, we can combine genetics, molecular manipulations, in vitro culture techniques, and classical embryology to investigate cell differentiation, patterning, and key signaling molecules in development.
Using these techniques, we hope to build a comprehensive picture of the fundamental mechanisms that underlie the coordinated growth and interdependence of blood vessels and organs. Understanding these principles will help us to identify and characterize molecular lesions that underlie human birth defects and disease.
