Meet the PI

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W. Lee Kraus, Ph.D.

Professor and Director | Cecil H. and Ida Green Center for Reproductive Biology Sciences (2010 - present)

Cecil H. and Ida Green Distinguished Chair in Reproductive Biology Sciences (2010-present)

Professor | Obstetrics & Gynecology and Pharmacology (2010-present)

Vice Chair for Basic Sciences | Department of Obstetrics & Gynecology (2010-present)

Assistant Director for Basic Research | Harold C. Simmons Comprehensive Cancer Center (2019-present)

Assistant Dean for Research Development | UT Southwestern Medical Center (2022-present)


W. Lee Kraus, Ph.D. is Professor and Director of the Green Center for Reproductive Biology Sciences, an endowed basic science research center at UT Southwestern with a research focus on signaling, gene regulation, and genomics in reproduction, development, and cancer.

Prior to his move to UT Southwestern in 2010, he was on the faculty in the Department of Molecular Biology and Genetics at Cornell University in Ithaca, NY and the Department of Pharmacology at Weill Cornell Medicine for 10 years, where he moved through the ranks from assistant professor to full professor.

Dr. Kraus’s research interests include signal regulated transcription, chromatin and gene regulation, nuclear receptors, PARPs, and NAD+ metabolism and signaling. He has been active in these fields as a scientist, conference organizer, journal editor, editorial board member, NIH grant reviewer, frequent manuscript reviewer, teacher, and consultant. Dr. Kraus has published over 150 original research articles in peer-reviewed journals, many in leading science journals, with an h-index of 77 (Google Scholar 2022).

During his independent scientific career, Dr. Kraus has been supported by a Career Award in the Biomedical Sciences/Reproductive Biology from the Burroughs Wellcome Fund, as well as grants from the National Institutes of Health, the American Cancer Society, the Cancer Prevention and Research Institute of Texas, the Endocrine Society, and the National Science Foundation.

Dr. Kraus has been an active and successful mentor, as of 2022 having trained 22 doctoral students, 26 postdocs, and 16 clinical fellows. Almost all of his former trainees have gone on to faculty positions in universities or private research institutes, research scientist positions in the biotech and pharma industries, or administrative positions in academia.

Dr. Kraus is also active in the biotech and pharma industries. He is a founder of Ribon Therapeutics, Inc. and ARase Therapeutics, Inc. - two oncology therapeutics companies in the PARP and ADP-ribosylation space. He also serves on the scientific advisory boards of other biotech start-up companies.

Dr. Kraus earned a Bachelor of Science degree from Cornell University in 1989. He then completed graduate research on the regulation of steroid hormone receptor activity in the laboratory of Benita S. Katzenellenbogen, Ph.D., at the University of Illinois, Urbana-Champaign, and received his Ph.D. in 1994. Dr. Kraus did his postdoctoral research on the mechanisms of transcriptional regulation with chromatin in the laboratory of Jim Kadonaga, Ph.D., at the University of California, San Diego. During his postdoctoral work, Dr. Kraus was supported by fellowships from the National Institutes of Health and the American Cancer Society, California Division.  

Dr. Kraus has won numerous research and teaching awards, including the Endocrine Society’s Richard E. Weitzman Memorial Award for research excellence (2007), the Endocrine Society’s Ernst Oppenheimer Award for research excellence (2014), the Cornell University College of Agriculture and Life Sciences Young Faculty Teaching Excellence Award (2004), and the Cornell University College of Agriculture and Life Sciences Excellence in Undergraduate Research Mentoring Award (2008).