Reproductive Biology

As an undergraduate student at Cornell University and as a graduate student at the University of Illinois, Dr. Kraus was trained as a reproductive biologist, focusing on various aspects of steroid hormone signaling in the female reproductive tract. His work as a graduate student in the laboratory of Dr. Benita Katzenellenbogen helped to define the molecular mechanisms by which estrogen signaling regulates the expression of the progestin receptor in the uterus. Now, during his time as director of the Green Center for Reproductive Biology Sciences at UT Southwestern, the Kraus Lab has expanded these studies into other reproductive organs, including the cervix, ovary, and placenta. We have brought our interests in the molecular mechanisms of gene regulation by steroid hormone receptors to bear on fundamental questions in these tissues.

Selected Publications

Fogarty E.A., Matulis C.K., Kraus W.L. (2012) Activation of estrogen receptor α by raloxifene through an activating protein-1-dependent tethering mechanism in human cervical epithelial cancer cells: a role for c-Jun N-terminal kinase. Molecular & Cellular Endocrinology 348:331-338. PMCID: PMC3217792

Willcockson A.R., Nandu T., Liu C.L., Nallasamy S., Kraus W.L., Mahendroo M. (2018) Transcriptome signature identifies distinct cervical pathways induced in lipopolysaccharide-mediated preterm birth. Biology of Reproduction 98:408-421. PMCID: PMC6279112

Vasquez Y.M, Nandu TS, Kelleher AM, Ramos EI, Gadad S.S, Kraus W.L. (2020) Genome-wide analysis and functional prediction of the estrogen-regulated transcriptional response in the mouse uterus. Biology of Reproduction 102:327-338. PMCID: PMC7016285

Kelleher A.M., Setlem R., Dantzer F., DeMayo F.J., Lydon J.P., Kraus W.L. (2021) Deficiency of PARP-1 and PARP-2 in the mouse uterus results in decidualization failure and pregnancy loss. Proc Natl Acad Sci USA 118:e2109252118. PMID: 34580230