Lab Members

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Palak Ahuja, Ph.D.

Postdoctoral Fellow

Publications

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Sridevi Challa, Ph.D.

Postdoctoral Fellow

Sridevi is interested in understanding the molecular crosstalk between metabolites and signaling pathways in cancer. Utilizing various cell biology and biochemical tools developed by the Kraus Lab, she is deciphering the cytosolic processes commonly regulated by enzymes in NADbiosynthesis pathways and PARPs in ovarian cancer.


Publications

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Andrea Edwards, Ph.D.

Postdoctoral Fellow

I joined the Kraus lab in March 2021. I am interested in the functional contribution of oncohistones to breast cancer tumorigenesis. I will be investigating histone mutations that target known/putative sites of ADP-ribosylation using various genomic strategies, cell-based/xenograft assays, CRISPR-Cas9, and other approaches. My studies propose that cancer utilizes mutations at sites of ADP-ribosylation to evade cell regulation, leading to enhanced proliferation and tumorigenesis.

I obtained my doctorate from the University of Arkansas for Medical Sciences in Interdisciplinary Biomedical Sciences. I investigated protein-DNA interactions between PARP-1 and oxidized G-Quadruplex DNA, highlighting a potentially novel repair mechanism that allows cancer cells to tolerate oxidative stress.


Publications

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Minjung Kwon, Ph.D.

Postdoctoral Fellow

With a variety of omics and biochemical tools, I investigate regulatory roles of TF ADP-ribosylation determining breast cancer subtype specificity. Final aims of the research are focused on connections between catalytic activity of PARP1, relevant TFs ADP-ribosylation, and therapeutic outcomes for subtype specific treatment.

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Komal Pekhale, Ph.D.

Postdoctoral Fellow

 

Xinrui Tan, M.D., Ph.D.

Visiting Instructor

 

 

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Hyung Bum Kim

Graduate Student

 

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Weidan Song

Graduate Student

I am interested in understanding the effect of different activators, such as snoRNAs, on the poly(ADP-ribosyl)lation activity of poly(ADP-ribose) polymerases-1 (PARP1).

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MiKayla Stokes

Graduate Student

 

 

 

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Amy Whitaker

Graduate Student

Amy is interested in understanding the role of poly(ADP-ribosyl)ation by nuclear poly(ADP-ribose) polymerases (PARPs) enzymes in signal-dependent control of transcription factor activity, enhancer formation, and target gene expression in adipogenesis and macrophage activation. Her favorite transcription factor is C/EBPβ and she is dedicated to studying the role of PARylation of C/EBPβ within these biological systems. Additionally, she is interested in utilizing PAR-Trackers to detect fluctuating levels of PARylation in living mice.


Publications

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    Steven Blaine Holloway, M.D.

    Gyn/Onc Clinical Fellow

    I am excited to take the charge of advancing clinical care and the cutting edge as a growing physician scientist.  My role in the Kraus lab is to investigate novel therapies and their mechanisms of action and resistance in gynecologic cancers, in order to better understand the underlying biology and explore new avenues of therapeutic strategy.  The plethora of advanced basic science tools available in this lab and in collaboration with the Green Center and UTSW will allow for complex analysis and power to answer difficult questions.

    Dr. Holloway is a Gynecologic Oncology fellow, who completed his M.D. training at UT Southwestern in Obstetrics and Gynecology.

    Christopher Walker, M.D.

    Gyn/Onc Clinical Fellow

     

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    Tulip Nandu, M.S.

    Computational Biologist III

    My expertise is in designing the data analysis pipelines, writing algorithms for sophisticated data analysis, and integration of various genomics assays to understand the complex regulation mechanisms of cancer, reproductive biology, endocrinology, and inflammation.  As a computational biologist at UT Southwestern (2013-present), I have been working on various data-driven projects, which need efficient analysis and interpretation to have a better understanding of signal-regulated transcription using genomics.  I am an expert in complex data analysis of Global Run-On Sequencing (GRO-seq), ATAC-seq, ChIP-seq, MeDIP-seq, RNA-seq, PRO-seq, ChIA-PET and various other next generation sequencing techniques and have automated the pipelines for some of them. My expertise has helped me in designing and analyzing scRNAseq data of Mouse decidual leukocytes to identify gestational changes in the immune cell landscape. I have developed pipelines and methodologies for compelling visualization for the sequencing data and metrics in R and Python for projects pertaining to characterization of potential biomarkers in Cervical and Uterine Endometrial Cancer. I have also conducted various Bioinformatics workshops to provide genomic data analysis training to the researchers in the scientific community. I believe that my combination of computational skills with strong background in biology from my undergrad has been extremely helpful in my career as a Computational Biologist.

    Publications

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    Nabina Paudyal, Ph.D.

    Computational Biologist I

    Working as a computational biologist I in Kraus Lab I am interested in understanding wide range of bioinformatics approaches to unleash the fundamental questions ranging from biochemistry to genomics. Understanding of downstream biological pathways, differential gene expressions, visualization of variety of data coming from genomics or proteomics platforms, incorporating existing tools and introducing new tools to elucidate new facets of proteome, genome and transcriptome are some of the works that I am mostly interested in. 

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    Shu-Ping Chiu, M.S.

    Research Assistant II

    My work contributes to the successful flow of experimentation and research executed by postdoctoral fellows, graduate students, and research staff. I am interested in using my expertise in molecular biology for biochemical assays.

    I am an AALAS-certified technician, RALAT, and participate in various studies involving animal models.

    I obtained my Master of Science degree from Fu-Jen Catholic University in Taiwan.


    Publications

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    Amy Gong, M.S.

    Research Associate

    Research areas that involve in DNA damage and repair, tumor microenvironment, cancer immunotherapy. General interests in pharmaceutical industry and drug development to discover transformative molecules through cutting-edge science and translate them into therapies for patients.

    Publications

      Charles Renshaw

      Research Assistant I

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      Luka Zrnic

      Research Technician II

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      Josue Zuniga

      Research Technician II