We are a group of physicists, biophysicists, cell biologists, and “computationalists” interested in the spatiotemporal organization of cell surface receptors, the mechanisms underlying it, and its consequences for cell signaling. We utilize light microscopy, particularly single-molecule and super-resolution imaging, to monitor molecular behavior in its native cellular environment, and we develop computer vision and machine learning approaches to quantitate the observed behavior and gain insight beyond what the eye can see.

We are interested in how membrane cholesterol controls diverse cellular signaling pathways to ensure lipid homeostasis, enable cell growth, and protect against infections. 

We use live-cell microscopy, nano-rheology, and synthetic biology to understand oocyte ageing, embryogenesis, and cancer onset.

Jan’s Lab is interested in understanding the dynamics of protein-RNA complexes during ribosome biogenesis. We are particularly focused on the roles of ATPases in coordinating ribosomal RNA processing and remodeling events, as well as the importance of these enzymes in signaling between the ribosome biogenesis pathway and the cell cycle machinery.

The Zhang lab studies intra- and inter-molecular interactions to understand how signaling proteins are regulated, using biochemistry, X-ray crystallography, cryo-EM and cell biology.

We are developing inhibitors of pyrimidine biosynthesis and polyamine biosynthesis to treat malaria and African sleeping sickness. We study polyamine and nucleotide metabolism in African trypanosomes to learn about novel metabolism and regulation.

Corey Lab is using nucleic acids or nucleic acid mimics to explore important cellular processes, develop novel therapeutic tools and strategies.

Saelices Lab employs crystallography and cryo-EM to study amyloid deposition and design anti-amyloid tools.

The Rosen Lab seeks to understand the formation, regulation, functions and internal structures of membraneless cellular compartments termed biomolecular condensates.