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In the Izumi Lab, with the ultimate goal of identifying druggable molecules/pathways in pediatric genetic disorders, we investigate the molecular mechanisms of pediatric genetic disorders due to chromosomal abnormalities and chromatin protein mutations. We employ novel genetic approaches by using patient-derived samples, induced pluripotent stem cell models and mutant mouse models.
Our lab studies the fundamental mechanisms of how commensal fungi survive and persist within a host niche filled with a multitude of innate and adaptive immune effectors, under both homeostatic and inflammatory conditions. We aim for our study to provide unique insights into human diseases, such as asthma, inflammatory bowel disease, and cancer, and provides the foundation for novel immunotherapeutic approaches.
The Robertson Lab studies mitochondrial and metabolic homeostasis in the corneal epithelium and the role of homeostatic dysfunction in the pathophysiology of corneal disease.
Harnessing the power of light to develop methods to understand, diagnose, & treat diseases. The unique strength of the Achilefu Lab (Optical Radiology Lab, ORL) is the ability to develop complete solutions from conception, implementation, and validation to human clinical care. We aim to change the way medicine is practiced.
The Tambar Group develops new strategies and concepts in synthetic chemistry to address challenging problems in chemistry and biology.
The Dr. Zou's CPI lab is directed by Dr. Qing Zou and it works closely with a cross-disciplinary team (clinicians, scientists, fellows) to develop and translate novel MRI techniques for cardiopulmonary MRI for patients with congenital and acquired heart diseases. The research involves different aspects of MRI, including image acquisition and reconstruction, post-processing, quantitative image analysis, pre-clinical investigation, and clinical translation and evaluation. The lab has access to a cardiac-dedicated clinical 1.5T scanner (Philips), a research-dedicated low-field 0.55T MR scanner (Siemens), three research-dedicated 3T scanners (Philips, Siemens, GE). The lab also has access to a high-field 7T research scanner (Philips) for research on the high-field scanner. Some of the scanners also have the capability to do multi-nuclear imaging.
The Farrar Lab is interested in understanding how external signals regulate immune cell function and development.
The Thinwa lab studies neurotropic viruses, host defense pathways, autophagy and brain development.
BiMIR aims at pushing the state of the art in clinical diagnosis and benefit to patients by developing novel medical imaging technologies and enhancing our understanding of the underlying tissue health conditions.
The Solmonson lab is interested in how the placenta senses and achieves metabolic homeostasis between the adult and fetal compartments during pregnancy.
Dr. Chalak’s lab focuses on improving neonatal neurologic care and outcomes for vulnerable babies through the NeuroNICU clinical program, Neonatal Neurology Fellowship, and NIH research program.
A major focus of the Horton lab is to determine how these transcriptional regulators contribute to the development of steatosis in various disease processes such as diabetes, obesity, and beta-oxidation defects. A second area of investigation centers on determining the function of PCSK9, a protein that is involved in determining plasma LDL cholesterol levels through its ability to post-transcriptionally regulate the expression of the LDL receptor in liver.
We are interested in how membrane cholesterol controls diverse cellular signaling pathways to ensure lipid homeostasis, enable cell growth, and protect against infections.
The Gospocic group studies how epigenetic pathways and gene expression regulate brain plasticity in the context of social behavior and aging by working with a unique ant species Harpegnathos saltator. We take a multidisciplinary approach and combine functional genomics, biochemistry, and behavioral assays in H. saltator, as well as the conventional Drosophila and mouse models to expedite genetic screening and provide evolutionary context to identified epigenetic pathways.
Specialty Areas: epigenetics, chromatin biology, gene regulation, social behavior, aging, neurodegeneration
Our laboratory aims to understand the role of metabolic adaptive mechanisms in cancer progression.
The Ye Lab is broadly interested in lipid-mediated signaling reactions.
Through our expertise, our expert team is leading the charge to develop more effective alternate therapies for urinary tract infections.
The UT Larynx Lab is a collaboration between The University of Texas at Dallas and UT Southwestern. Our research focuses on the role of the larynx in vocal production and sensorimotor voice and breathing disorders.
The Henning lab develops novel ultra-high field MRI and metabolic MRI methodology for human application and translates it to neuroscientific, physiological and clinical trials in brain, spine, heart and muscle disorders.
We aim to elucidate the role of the innate immune system in damage and repair following ischemic and hemorrhagic insults to the brain. We are specifically focused on innate immune drivers of secondary injury following aneurysmal subarachnoid hemorrhage and the immune response triggered by acute intracranial pressure spikes during aneurysm rupture. We also look into promoting recovery after ischemic stroke by reprogramming microglia and peripheral myeloid cells to drive repair. In addition, we are pursuing the development of therapeutics for intraarterial immunomodulation for chronic subdural hemorrhage.
