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Our lab is using various approaches to explore this biology and develop new treatments with a focus on targeting tumor intrinsic factors such as genetic programs like the epithelial to mesenchymal transition that coordinate with infiltrating immune cells in enhance therapeutic resistance and assist distant spread.
Our goal is to track the signaling dynamics of individual effectors and toxins in living cells, using a combination of fluorescent genetic reporters, microinjection of labeled bacterial proteins, and live cell imaging techniques.
The Arteaga laboratory has a longstanding interest in understanding the molecular pathways that drive breast cancer progression and influence response to therapies.
The ultimate goal of the Kittler Lab's research is to develop novel therapeutic approaches that target transcription factors, which play important roles in common solid tumors (brain, breast, lung and prostate cancer) and could therefore have translational potential.
Tsai Lab studies the cellular and molecular mechanisms of synapse and neural circuit development.
Our research focuses on two main areas: hyperpolarized 13C, 15N, 89Y and 107, 109Ag compounds, and conventional lanthanide-based T1 shortening and paraCEST imaging agents.
Our laboratory has characterized many of the transporters responsible for proximal tubule acidification and solute transport
The Kraus Lab is interested in the basic mechanisms of nuclear signaling and gene regulation by small molecules and how these signaling pathways relate to human physiology and disease states.
Our research is largely aimed at understanding how an organism detects mechanical force.
Mukhopadhyay Lab research aims to understand how the primary cilium regulates downstream pathways to ultimately drive morphogenesis in different tissues. We undertake a multi-pronged approach including proteomics, cell biology, biochemistry, reverse genetics, and generation of innovative mouse models to study regulation of signaling pathways by cilia in in cellular and organismal contexts.
Our lab focuses on the molecular and cellular mechanisms underlying cell fate specification during blood vessel development and organogenesis.
Roberts Lab focuses on understanding the cellular and circuit mechanisms for behavioral learning, learning from social experiences and from example.
The significance of our research is to show effective anti-Aβ42 antibody production in large animals and safety of DNA Aβ42 immunotherapy in these models to proceed with vaccination in patients at risk for Alzheimer’s disease.
Zaki Lab's research focuses on the the study of gastrointestinal inflammation and cancer.
Our research is aimed at innovating and translating computational technology to advance biomedical research and medical diagnoses/treatments.
The Seemann Lab studies the molecular mechanisms governing the function and inheritance of the mammalian Golgi apparatus.
Our lab is working with to develop a gene therapy that would allow increased Ube3a expression in the paternal copy of the gene that causes Angelman syndrome.
Our lab researches Cerebellar Dysfunction, Brainstem Dysfunction, High-Throughput Screen, and Human Studies.
Akbay Lab studies genetic and molecular events that lead to lung-tumor initiation and immune evasion.
The Smith Lab strives to develop enabling tools for organic synthesis, allowing bioactive molecules of great complexity to be prepared in a concise and sustainable fashion.
