Developmental Biology Cover Article on Forebrain development
Role of Gpr161 in forebrain development.
Immunofluorescence image of mouse postnatal day 0 cingulate cortex from conditional knockout of the G-protein-coupled receptor, Gpr161 stained for cortical neuron markers Satb2 (red) and FoxP1 (green) showing excess gyrus formation (polymicrogyria). Shimada et al. demonstrate that derepression of sonic hedgehog signaling upon Gpr161 deletion causes forebrain defects such as that shown in the image, and ventricular abnormalities, including ventriculomegaly and periventricular nodular heterotopia. Image constructed by Bandarigoda N. Somatilaka and John Shelton. See article by Shimada et al., pages 47-62 in volume/issue 450/1.