Publications

Featured Publications

Permanent deconstruction of intracellular primary cilia in differentiating granule cell neurons.

Ott CM, Constable S, Nguyen TM, White K, Lee WA, Lippincott-Schwartz J, Mukhopadhyay S, 2024 Oct J Cell Biol 10 223

A defined tubby domain β-barrel surface region of TULP3 mediates ciliary trafficking of diverse cargoes.

Palicharla VR, Badgandi HB, Hwang SH, Legué E, Liem KF, Mukhopadhyay S, 2024 Nov Mol Biol Cell mbcE24090426

Molecular and structural perspectives on protein trafficking to the primary cilium membrane.

Reddy Palicharla V, Mukhopadhyay S, 2024 Jun Biochem Soc Trans

GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway.

Hoppe N, Harrison S, Hwang SH, Chen Z, Karelina M, Deshpande I, Suomivuori CM, Palicharla VR, Berry SP, Tschaikner P, Regele D, Covey DF, Stefan E, Marks DS, Reiter JF, Dror RO, Evers AS, Mukhopadhyay S, Manglik A, 2024 Feb Nat Struct Mol Biol

Programmed withdrawal of cilia maintenance followed by centriole capping leads to permanent cilia loss during cerebellar granule cell neurogenesis

Sandii Constable, Carolyn M. Ott, Andrew L. Lemire, Kevin White, Amin Lim, Jennifer Lippincott-Schwartz, Saikat Mukhopadhyay 2024 BioRxiv

Context-dependent ciliary regulation of hedgehog pathway repression in tissue morphogenesis.

Hwang SH, White KA, Somatilaka BN, Wang B, Mukhopadhyay S, 2023 Nov PLoS Genet 11 19 e1011028

Interactions between TULP3 tubby domain and ARL13B amphipathic helix promote lipidated protein transport to cilia.

Palicharla VR, Hwang SH, Somatilaka BN, Legué E, Shimada IS, Familiari NE, Tran VM, Woodruff JB, Liem KF, Mukhopadhyay S, 2023 Jan Mol Biol Cell mbcE22100473

Human IFT-A complex structures provide molecular insights into ciliary transport.

Jiang M, Palicharla VR, Miller D, Hwang SH, Zhu H, Hixson P, Mukhopadhyay S, Sun J, 2023 Feb Cell Res

Cilia-Localized Counterregulatory Signals as Drivers of Renal Cystogenesis.

Walker RV, Maranto A, Palicharla VR, Hwang SH, Mukhopadhyay S, Qian F, 2022 Front Mol Biosci 9 936070

Ciliary and extraciliary Gpr161 pools repress hedgehog signaling in a tissue-specific manner.

Hwang SH, Somatilaka BN, White K, Mukhopadhyay S, 2021 Aug Elife 10

Developmental and regenerative paradigms of cilia regulated hedgehog signaling.

Kopinke D, Norris AM, Mukhopadhyay S, 2020 Jun Semin. Cell Dev. Biol.

Ankmy2 Prevents Smoothened-Independent Hyperactivation of the Hedgehog Pathway via Cilia-Regulated Adenylyl Cyclase Signaling.

Somatilaka BN, Hwang SH, Palicharla VR, White KA, Badgandi H, Shelton JM, Mukhopadhyay S, 2020 Jul Dev. Cell

Derepression of sonic hedgehog signaling upon Gpr161 deletion unravels forebrain and ventricular abnormalities.

Shimada IS, Somatilaka BN, Hwang SH, Anderson AG, Shelton JM, Rajaram V, Konopka G, Mukhopadhyay S 2019 Mar Dev. Biol.

Tulp3 Regulates Renal Cystogenesis by Trafficking of Cystoproteins to Cilia.

Hwang SH, Somatilaka BN, Badgandi H, Palicharla VR, Walker R, Shelton JM, Qian F, Mukhopadhyay S 2019 Feb Curr. Biol.

Basal Suppression of the Sonic Hedgehog Pathway by the G-Protein-Coupled Receptor Gpr161 Restricts Medulloblastoma Pathogenesis.

Shimada IS, Hwang SH, Somatilaka BN, Wang X, Skowron P, Kim J, Kim M, Shelton JM, Rajaram V, Xuan Z, Taylor MD, Mukhopadhyay S 2018 Jan Cell Rep 5 22 1169-1184

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins.

Badgandi HB, Hwang SH, Shimada IS, Loriot E, Mukhopadhyay S 2017 Feb J. Cell Biol.

The G-protein-coupled receptor Gpr161 regulates forelimb formation, limb patterning and skeletal morphogenesis in a primary cilium-dependent manner.

Hwang SH, White KA, Somatilaka BN, Shelton JM, Richardson JA, Mukhopadhyay S 2017 Dec Development

Smoothened determines β-arrestin-mediated removal of the G protein-coupled receptor Gpr161 from the primary cilium

Pal K, Hwang SH, Somatilaka B, Badgandi H, Jackson PK, DeFea K, Mukhopadhyay S 2016 Mar J. Cell Biol.

The Ciliary G-Protein-Coupled Receptor Gpr161 Negatively Regulates the Sonic Hedgehog Pathway via cAMP Signaling.

Mukhopadhyay S, Wen X, Ratti N, Loktev A, Rangell L, Scales SJ, Jackson PK 2013 Jan Cell 1-2 152 210-223

TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia.

Mukhopadhyay S, Wen X, Chih B, Nelson CD, Lane WS, Scales SJ, Jackson PK 2010 Oct Genes Dev. 19 24 2180-93

Studying Hedgehog Signaling During Mouse Neural Tube Development.

Constable S, White K, Somatilaka BN, Mukhopadhyay S, 2022 Methods Mol Biol 2374 59-71

A pathogenic variant of TULP3 causes renal and hepatic fibrocystic disease.

Jafari Khamirani H, Palicharla VR, Dastgheib SA, Dianatpour M, Imanieh MH, Tabei SS, Besse W, Mukhopadhyay S, Liem KF, 2022 Front Genet 13 1021037

Wnt1 Lineage Specific Deletion of Gpr161 Results in Embryonic Midbrain Malformation and Failure of Craniofacial Skeletal Development.

Kim SE, Robles-Lopez K, Cao X, Liu K, Chothani PJ, Bhavani N, Rahman L, Mukhopadhyay S, Wlodarczyk BJ, Finnell RH, 2021 Front Genet 12 761418

Ubiquitin Tunes Hedgehog in Matters of the Heart.

Constable S, Mukhopadhyay S, 2020 Nov Dev Cell 4 55 385-386

Cellular signalling by primary cilia in development, organ function and disease.

Anvarian Z, Mykytyn K, Mukhopadhyay S, Pedersen LB, Christensen ST 2019 Feb Nat Rev Nephrol

Dominant negative GPR161 rare variants are risk factors of human spina bifida.

Kim SE, Lei Y, Hwang SH, Wlodarczyk BJ, Mukhopadhyay S, Shaw GM, Elizabeth Ross M, Finnell RH 2018 Sep Hum. Mol. Genet.

Trafficking to the primary cilium membrane.

Mukhopadhyay S, Badgandi HB, Hwang SH, Somatilaka B, Shimada IS, Pal K 2017 Jan Mol. Biol. Cell 2 28 233-239

Using Primary Neurosphere Cultures to Study Primary Cilia.

Shimada IS, Badgandi H, Somatilaka BN, Mukhopadhyay S 2017 Apr J Vis Exp 122

G-protein-coupled receptor signaling and neural tube closure defects.

Shimada IS, Mukhopadhyay S 2016 Oct Birth Defects Res. Part A Clin. Mol. Teratol.

TCTEX1D2, a potential link to skeletal ciliopathies.

Mukhopadhyay S 2015 Jan Cell Cycle 0

Studying G protein-coupled receptors: immunoblotting, immunoprecipitation, phosphorylation, surface labeling, and cross-linking protocols.

Pal K, Badgandi H, Mukhopadhyay S 2015 Methods Cell Biol. 127 303-22

Primary cilium and sonic hedgehog signaling during neural tube patterning Role of GPCRs and Second Messengers.

Pal K, Mukhopadhyay S 2014 May Dev Neurobiol

G-protein-coupled receptors, Hedgehog signaling and primary cilia.

Mukhopadhyay S, Rohatgi R 2014 May Semin. Cell Dev. Biol.

G-protein-coupled receptors and localized signaling in the primary cilium during ventral neural tube patterning.

Hwang SH, Mukhopadhyay S 2014 Jun Birth Defects Res. Part A Clin. Mol. Teratol.

Cilia, tubby mice, and obesity.

Mukhopadhyay S, Jackson PK 2013 Jan Cilia 1 2 1

An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium.

Wright KJ, Baye LM, Olivier-Mason A, Mukhopadhyay S, Sang L, Kwong M, Wang W, Pretorius PR, Sheffield VC, Sengupta P, Slusarski DC, Jackson PK 2011 Nov Genes Dev. 22 25 2347-60

The tubby family proteins.

Mukhopadhyay S, Jackson PK 2011 Genome Biol. 6 12 225

Cis-regulatory mechanisms of gene expression in an olfactory neuron type in Caenorhabditis elegans.

Nokes EB, Van Der Linden AM, Winslow C, Mukhopadhyay S, Ma K, Sengupta P 2009 Dec Dev. Dyn. 12 238 3080-92

Sensory signaling-dependent remodeling of olfactory cilia architecture in C. elegans.

Mukhopadhyay S, Lu Y, Shaham S, Sengupta P 2008 May Dev. Cell 5 14 762-74

Elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase Rab8.

Omori Y, Zhao C, Saras A, Mukhopadhyay S, Kim W, Furukawa T, Sengupta P, Veraksa A, Malicki J 2008 Apr Nat. Cell Biol. 4 10 437-44

Distinct IFT mechanisms contribute to the generation of ciliary structural diversity in C. elegans.

Mukhopadhyay S, Lu Y, Qin H, Lanjuin A, Shaham S, Sengupta P 2007 Jun EMBO J. 12 26 2966-80

Identification of thermosensory and olfactory neuron-specific genes via expression profiling of single neuron types.

Colosimo ME, Brown A, Mukhopadhyay S, Gabel C, Lanjuin AE, Samuel AD, Sengupta P 2004 Dec Curr. Biol. 24 14 2245-51