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SPIL is dedicated to advancing patient care through the development and validation of cutting-edge radionuclide imaging technologies for single photon emission computed tomography (SPECT) and positron emission tomography (PET). By harnessing the power of deep learning, we aim to address key limitations of PET and SPECT imaging—such as low spatial resolution and slow data acquisition—to significantly enhance diagnostic capabilities.
The overarching goals of our lab are to understand the posttranscriptional mechanisms of gene expression and regulation in the Kaposi's sarcoma-associated herpesvirus (KSHV) and its human host cell. We are particularly focused on the mechanisms and regulation of nuclear RNA stability, polyadenylation, and mRNA processing by viral and by host cell factors.
The Cotter Research Group is a clinical lab focused on strategies to improve outcomes for patients with liver diseases with a particular focus on alcohol and metabolic dysfunction-associated liver diseases.
The HMG CoA reductase regulatory system researched by DeBose-Boyd Lab involves a complex, multivalent feedback mechanism that is mediated by sterol and nonsterol end-products of mevalonate metabolism.
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The Yue lab focuses on developing translational immunology platforms to uncover the molecular and cellular mechanisms underlying immunotherapy resistance and to design next-generation cancer immunotherapies.
Research in the Rothermel Laboratory focuses on deciphering the molecular mechanisms that control cardiac structure and function during normal development and in response to pathological stress.
Multidisciplinary research to beat cancer
The Concussion, Acquired Brain Injury, and Neurodegeneration (CABIN) Laboratory, led by Kristin Wilmoth, Ph.D., investigates best practices for assessment and treatment of concussion and more severe traumatic brain injury, other acquired brain injuries such as stroke, and neurodegenerative conditions such as Alzheimer's disease.
Learn more about the Families and Health Lab.
In the Izumi Lab, with the ultimate goal of identifying druggable molecules/pathways in pediatric genetic disorders, we investigate the molecular mechanisms of pediatric genetic disorders due to chromosomal abnormalities and chromatin protein mutations. We employ novel genetic approaches by using patient-derived samples, induced pluripotent stem cell models and mutant mouse models.
Our lab studies the fundamental mechanisms of how commensal fungi survive and persist within a host niche filled with a multitude of innate and adaptive immune effectors, under both homeostatic and inflammatory conditions. We aim for our study to provide unique insights into human diseases, such as asthma, inflammatory bowel disease, and cancer, and provides the foundation for novel immunotherapeutic approaches.
The Robertson Lab studies mitochondrial and metabolic homeostasis in the corneal epithelium and the role of homeostatic dysfunction in the pathophysiology of corneal disease.
Harnessing the power of light to develop methods to understand, diagnose, & treat diseases. The unique strength of the Achilefu Lab (Optical Radiology Lab, ORL) is the ability to develop complete solutions from conception, implementation, and validation to human clinical care. We aim to change the way medicine is practiced.
The Tambar Group develops new strategies and concepts in synthetic chemistry to address challenging problems in chemistry and biology.
The Dr. Zou's CPI lab is directed by Dr. Qing Zou and it works closely with a cross-disciplinary team (clinicians, scientists, fellows) to develop and translate novel MRI techniques for cardiopulmonary MRI for patients with congenital and acquired heart diseases. The research involves different aspects of MRI, including image acquisition and reconstruction, post-processing, quantitative image analysis, pre-clinical investigation, and clinical translation and evaluation. The lab has access to a cardiac-dedicated clinical 1.5T scanner (Philips), a research-dedicated low-field 0.55T MR scanner (Siemens), three research-dedicated 3T scanners (Philips, Siemens, GE). The lab also has access to a high-field 7T research scanner (Philips) for research on the high-field scanner. Some of the scanners also have the capability to do multi-nuclear imaging.
The Farrar Lab is interested in understanding how external signals regulate immune cell function and development.
The Thinwa lab studies neurotropic viruses, host defense pathways, autophagy and brain development.
BiMIR aims at pushing the state of the art in clinical diagnosis and benefit to patients by developing novel medical imaging technologies and enhancing our understanding of the underlying tissue health conditions.
The Solmonson lab is interested in how the placenta senses and achieves metabolic homeostasis between the adult and fetal compartments during pregnancy.
