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Mootha Lab uses human genetics and genomics to understand the molecular basis of Fuchs' endothelial corneal dystrophy and develop novel therapeutic strategies.

The Vernino Lab focuses on the mechanisms of autoimmune disorders of the nervous system, especially those associated with neurological autoantibodies. We use a variety of techniques including histology, and immunology.  This research is complemented by clinical therapeutic trials studying novel treatments for autoimmune encephalitis and autonomic disorders.

Zhang (Chun-Li) Lab research focuses on cellular plasticity in the adult nervous system and modeling human neurodegenerative diseases. We use cell culture and genetically modified mice as model systems. Molecular, cellular, electrophysiological, and behavioral methods are employed.

The Reddy Lab focuses on restoring effective antigen presentation to enhance anti-tumor immunity in breast cancers.

We are interested in building small organic molecules and studying their functions in biological systems. Our lab started in 2004 using state-of-the-art tools to address challenging issues in the field of natural product synthesis. 

The Acute Liver Failure Study Group (ALFSG) is a clinical research network funded by the National Institutes of Health since 1997, to gather important prospective data and biosamples on this rare condition. 

The Wang Lab uses chemical biology tools to study the molecular mechanisms underlying interesting bacterial behaviors.

We apply advanced MRI technologies to study many different diseases.

Dr. Wang's research interests primarily involve the development of statistical methodologies for the design and analysis of clinical trials, as well as the evaluation of correlated data and repeated measurements. Her specific focus has been on power analysis, experimental design, and sample size determination for longitudinal studies using Frequentist and Bayesian approaches. Dr. Wang has also developed the methodologies that are very flexible and can accommodate various pragmatic issues such as longitudinal and clustered outcomes, random variability in cluster size, unbalanced randomization, complicated correlation structures, missing data, and small sample sizes. Those methodologies have achieved great performances across a broad spectrum of design configurations and made innovative contributions to clinical studies.

We study ion channel clusters. To study such clusters without the complications arising from the complex cellular environment, components from cells are purified and studied in isolation.

The Welch Lab has a primary interest in developing materials and medical devices for use in treatment of congenital heart disease.

Translational Research in UltraSound Theranostics (TRUST) Lab at UT Southwestern

The Oh lab is committed to elucidating how G protein-coupled Receptor (GPCR) works in regulating metabolism and identifying new avenues for developing therapeutics to treat metabolic syndromes such as type 2 diabetes, insulin resistance.

The Center for Depression Research and Clinical Care (CDRC) is nationally recognized for its cutting-edge research in unipolar and bipolar depression. The research conducted within the center brings better understanding of the causes of depression, identifies effective new treatments, and improves existing ones.

Welcome to the PARK Lab.

Our lab focuses on:

1. Development of novel noninvasive imaging methods for in vivo metabolism and function
2. Identification of characteristics in metabolic diseases
3. Clinical translations of the metabolic imaging methods

Kidney disease has reached epidemic proportions in the U.S. The Carroll Lab performs basic and translational research focused on kidney development, maintenance and regeneration. 

We are interested in the function of chromatin regulation of signaling pathways important for neural development, brain tumor growth and autism pathogenesis. 

The Goss lab collaborates with a multidisciplinary group of researchers to study the heart and lungs long after preterm birth. We are part of the Parkland Outcomes after Prematurity Study (POPS), which conducts collaborative research on outcomes of prematurity from birth through adulthood.

The focus of our current research is the biochemistry and molecular characterization of ABCG5/ABCG8 transporter, aiming at understanding the mechanism by which this transport system operates to translocate cholesterol cross membranes.

The goal of our research is to identify key immune checkpoints of gastrointestinal disorders that could be targeted for therapeutic intervention and drug development.