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We utilize computational modeling and physical experiments at multiple biological scales to perform translational biomechanics and mechanobiology research with a particular focus on women's health and skeletal muscle.

Dr. Brunoni's research focuses on developing innovative therapeutic strategies using transcranial direct current stimulation, transcranial magnetic stimulation, and other neuromodulation techniques for treating major depressive disorder, bipolar disorder, OCD, schizophrenia, and post-COVID cognitive symptoms.

The Cardiovascular Pharmacotherapy Research Lab integrates molecular epidemiology, clinical pharmacology, clinical trials and population health science to identify new pathways and therapeutic strategies for the prevention of heart failure. Our team conducts cross-disciplinary, mechanism-focused clinical research to translate biologic discoveries into interventions with meaningful public health impact.

Research lab at UT Southwestern for Mohan Krishnan, Ph.D.

Our laboratory is interested in studying the intersection between lung cancer and immunology. We are currently focused on co-opting innate immune signaling pathways and tumor-associated T cell populations to target diverse subsets of lung cancer.

The Sankary Neuroethics Lab at UT Southwestern explores the ethical dimensions of neuroscience and neurosurgical innovation.

Neuron-cancer interactions that promote tumor growth and disrupt neural circuits. 

The central goal of Dr. Asch's research is to uncover the mechanistic underpinnings of how stress and trauma affect brain function, with a particular emphasis on how these experiences shape mental health outcomes with the aim to contribute to the development of novel interventions designed to mitigate the harmful effects of stress and trauma, foster resilience, and ultimately improve overall 
health and well-being.

The Bartelt Lab is focused on understanding the epigenetic basis of cerebellar neurodegenerative disorders to develop holistic gene therapies. Using single-cell and spatial sequencing approaches, we profile healthy and diseased states to identify gene regulatory mechanisms in disease and utilize functional genomic tools to advance therapeutic approaches. 

Medical Artificial Intelligence and Automation

The Sweat lab studies how perturbations in cardiac gene expression result in arrhythmias, with a focus on atrial fibrillation. We apply single-cell multiomics and epigenetics approaches to gain insight into mechanisms of arrhythmia and potential new treatment approaches231`

The Voice Behavior and Rehabilitation Laboratory, led by Dr. Laura Toles, performs research in the field of Otolaryngology with focus on individual differences, personality and voice, phonotrauma, vocal behavior, and improving therapeutic outcomes.

Shi Lab focuses on developing AI systems for healthcare, with an emphasis on large language models, agentic AI, clinical informatics, personalized medicine, tool/retrieval-augmented learning, reasoning, and data-centric AI. 

The Kelesidis Lab studies the cross between viral infections and mechanisms of associated end organ damage with a goal to develop novel therapeutic treatments. 

The Schaffert Lab advances understanding of cognitive decline and recovery mechanisms by investigating (1) idiopathic normal pressure hydrocephalus, focusing on cognitive, neurobiological, and pathophysiological processes that shape impairment and postoperative recovery, and (2) long-term cognitive impairment and dementia following traumatic brain injury, with emphasis on identifying factors associated with persistent deficits, accelerated cognitive aging, and later-life neurodegenerative diagnoses.

Developing novel interventions for psychiatric disorders, personalizing the use of currently available treatments, and bringing these scientific discoveries to clinical practice.

The Lieber Lab studies life after liver transplantation — focusing on survivorship experiences of patients and their caregivers. Our research seeks to understand what it means to go through this life-saving and life-changing surgery. By listening to the voices of those who have lived it, we aim to improve transplant care, guide future programs, and help people achieve better long-term health and quality of life after transplant.

The Advanced Integrative Molecular Probe Collaboration's mission is to develop new imaging agents in a multidisciplinary approach to monitor, understand and cure disease at an early stage.

Located in the Department of Ophthalmology, the Campello Lab focuses on the molecular mechanisms of retinal aging and neurodegeneration, as well as the disease biology of inherited retinal disorders. Dr. Campello's lab develops gene-agnostic therapeutic strategies and engineers intravitreal gene therapies, bridging fundamental discover with translational innovation to preserve vision in aging and disease.

The Hernandez Lab explores structural, cellular, and mechanobiological aspects of sexual dimorphism and sex hormones in cartilage health and osteoarthritis.