Search Labs

Zaman’s Lab focuses on the design and development of novel cutting-edge multi-mode imaging systems to overcome current limitations in clinical systems. Most recent research project is involved with the design and developed of a multimode catheter-based imaging system called a Circumferential Intravascular Radioluminescence Photoacoustic Imaging (CIRPI) for early detection of thin-cap-fibro-atheroma (TCFA), the underlying causes of coronary artery disease, one of the leading causes of morbidity and mortality in the USA and worldwide. Further, the CIRPI system characterizes the plaques based on disease tissue compositions to unravel their complex structures. This CIRPI system integrates optical, photoacoustic, radioluminescence and ultrasound imaging. We seek to better understand the underlying causes of the disease mechanisms. We are dissecting the role of TCFA perturbations on vascular wall processes during atherosclerosis progression. Our lab also studying novel molecular imaging methods to study coronary arterial disease, carotid stenosis, and myocardial ischemia in subcellular level.

In the Zhang Lab, we seek to understand the molecular mechanisms of metabolic diseases, with the long-term goal of creating novel therapeutic strategies.

Our lab is interested in understanding the relationship between injury, regeneration, and cancer. We are focused on identifying the genes and mechanisms that regulate regenerative capacity in the liver and understanding how these contribute to hepatocellular carcinoma development.

We investigate the neuro-hormonal basis for complex eating behaviors and blood glucose control, with the ultimate goal of designing new methods to prevent and treat extremes of body weight, blood glucose, and associated disorders of mood and metabolism.