Search Labs

The Nanoimmune Therapeutics Lab’s mission is to develop and translate novel immunotherapies, with a particular focus on addressing malignant cancers in humans and animals.

The mission of Napierala Lab is to contribute to the development of therapies and a cure for Friedreich’s ataxia (FRDA) by elucidating molecular mechanisms causing the disease, developing novel cellular and animal models of FRDA, identifying disease biomarkers and testing novel therapeutic approaches.

Shawna D. (Smith) Nesbitt, M.D., M.S., studies hypertension in African-Americans, insulin resistance, and hyperlipidemia. 

The focus of the Neuromuscular Center is the diagnosis and treatment of muscle diseases known as metabolic myopathies, including inherited disorders of muscle fat, carbohydrate, and mitochondrial muscle metabolism.

We study bacterial colonization of the intestinal tract, to understand how both benign and pathological bacteria affect their environment. Our long-term goal is to treat intestinal diseases by genetically engineering bacteria in vivo.

The Nicastro Lab studies 3D ultra-structures and cell biological functions of macro-molecular complexes inside cells.

The Ank Nijhawan research team is focused on improving outcomes for people living with or at risk for HIV, and ensuring their access to comprehensive healthcare and social support services. We also focus on individuals involved in the criminal legal system, and specifically the overlap of infectious diseases such as HIV, hepatitis, sexually transmitted infections and substance use.

The ultimate goal of the Nijhawan lab aims is to discover first in class drugs for the treatment of cancer. 

Our lab works with murine disease models and employs Biochemistry, Molecular and Cell Biology to investigate brain glycogen metabolism and related neurodegenerative diseases.

The Noch Lab is a basic and translational research laboratory focused on identifying novel strategies to target metabolic vulnerabilities in glioma.

Research conducted by the Nomellini Lab utilizes animal models as well as human samples to examine the interaction between the innate and adaptive immune responses that occur after injury or infection, and the heterogeneity of the immune responses that occur in each individual. Led by Vanessa Nomellini, M.D., Ph.D., our lab ultimately aims to develop personalized immune therapies to reverse the immunosuppression that can occur in ICU survivors.

The Norgard Laboratory is engaged in three areas of infectious disease research: syphilis, Lyme disease, and tularemia.

The long-term goals of the Nwariaku Laboratory are to understand the cellular mechanisms that regulate endothelial dysfunction during inflammatory and neoplastic conditions with a hope to use this knowledge in designing novel therapeutic agents. 

O'Donnell Lab investigates mechanisms of tumor initiation, progression, and metastasis using molecular and biochemical studies and animal models.

The focus of the Obata Lab is to study how environmental signals (e.g., microbiota, diet, day/night cycles) shape intestinal neural circuits and immune cell networks. A variety of experimental techniques are used, including state-of-the-art imaging technologies, viral tracing of gut innervation, in vivo and ex vivo physiological assays, gnotobiotic systems and multi-omics technologies. The Obata lab is also interested in elucidating the molecular mechanisms of inter-organ communication, including the Gut-Brain axis.

The Oh lab is committed to elucidating how G protein-coupled Receptor (GPCR) works in regulating metabolism and identifying new avenues for developing therapeutics to treat metabolic syndromes such as type 2 diabetes, insulin resistance.

Olson Lab studies muscle cells as a model for understanding how stem cells adopt specific fates and how programs of cell differentiation and morphogenesis are controlled during development.

Orchard Lab at UT Southwestern Medical Center

The Orth lab is interested in elucidation the activity of virulence factors from pathogenic bacteria so that we can gain novel molecular insight into eukaryotic signaling systems.

The Osborne Lab focuses on how regulation of miRNA and mRNA controls the branching of developing cells, and how disregulation of these pathways contributes to aggressive tumor behavior.

The main research focus of the Otwinowski lab is on developing computational and statistical
methods and protocols for macromolecular structure determination using X-ray crystallography.

Oz Lab combines imaging, interventional radiology, radiotracers (novel and known), and animal models to study physiology and disease pathophysiology. 

The Pan laboratory uses Drosophila and mice as model systems to investigate size-control mechanisms in normal development and their pathological roles in cancer.

Our research is focused on mechanisms underlying acute kidney injury and sepsis.  Our laboratory has implicated mitochondrial maintenance via PGC1alpha and NAD+ as a novel pathway for resilience against acute physiological stressors.

Welcome to the PARK Lab.

Our lab focuses on:

1. Development of novel noninvasive imaging methods for in vivo metabolism and function
2. Identification of characteristics in metabolic diseases
3. Clinical translations of the metabolic imaging methods