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Chen (Kenneth) Lab

Chen lab studies how dysregulation of RNA synthesis and degradation drives childhood cancers with the ultimate goal of identifying new therapeutic vulnerabilities to exploit in treating them.

  • Kenneth Chen, M.D.
Childhood cancer
Cancer Biology

Chen (Zhijian "James") Lab

Chen Lab is broadly interested in mechanisms of signal transduction, namely how a cell communicates with its surroundings and within itself.

  • Zhijian "James" Chen, Ph.D.
Genetics, Development and Disease Immunology

Cheng (Jonathan) Lab

Jonathan Cheng's Lab performs a comprehensive suite of outcome measures to assess peripheral nerve recovery and chronic neural interfacing in the research setting.

  • Jonathan Cheng, M.D.
Peripheral nerve
Biomedical Engineering

Chiang Lab

My lab has a long-time interest in understanding the mechanisms of transcription and gene regulation in mammalian cells using initially cell-free systems reconstituted with purified gene-specific transcription factors, general cofactors, and components of the general transcription machinery to recapitulate transcriptional events in vitro. 

  • Cheng-Ming Chiang, Ph.D.
Gene regulation
Cancer Biology Cell and Molecular Biology

Choi (Changho) Lab

Magnetic resonance spectroscopy (MRS) provides an effective tool for detecting bio-chemicals in living systems noninvasively. Dr. Choi’s lab focuses on technical and clinical development of MR spectroscopy (MRS) in the brain in vivo.

  • Changho Choi, Ph.D.

Choi (Seungwon) Lab

Ascending somatosensory circuitry that shapes the perception of touch and pain. We study the development, function and dysfunction of ascending somatosensory pathways.

  • Seungwon Choi, Ph.D.
Genetics, Development and Disease Neuroscience

Chong Lab

The Chong Research group has been conducting clinical and translational research on cutaneous lupus including outcome measure development for clinical trials, biomarkers for diagnosis and prognosis, and disease outcomes.

  • Benjamin Chong, M.D.

Chook Lab

The Chook Lab studies physical and cellular mechanisms of Kaps. Our long-term goals are to understand how the macromolecular nuclear traffic patterns coordinated by the 20 human Kaps contribute to overall cellular organization.

  • Yuh Min Chook, Ph.D.

Christopher Lu Lab

We use in vivo models of ischemic acute kidney injury in mice, and in vitro model systems to perform detailed studies of proinflammatory genes activated by renal ischemia/reperfusion.

  • Christopher Lu, M.D.
Acute kidney injury transplant rejection chronic kidney disease

Chung Lab

Chung Lab uses primary human specimens, patient-derived xenograft models, and genetically engineered mouse models to study the molecular mechanisms underlying disease stem cell function in hematologic malignancies.

  • Stephen Chung, M.D.
Cancer Biology

Cleaver Lab

Our lab focuses on the molecular and cellular mechanisms underlying cell fate specification during blood vessel development and organogenesis.

  • Ondine Cleaver, Ph.D.
Genetics, Development and Disease

CMRU - Cardiometabolic Research Unit

The discovery of ANP many years ago sparked interest in the use of natriuretic peptides to diagnose and treat heart failure and other salt-retaining disorders. Since then, there have been successes and failures. A more comprehensive understanding of the natriuretic peptide system, including the role of noncardiac factors such as race/ethnicity, may encourage more targeted approaches. One of the original insights of de Bold et al, was that the heart is an endocrine organ. Endocrine therapies are administered to individuals with specific evidence of endocrine dysfunction, not to capture short-term beneficial effects. For instance, thyroid hormone is given only to patients in whom hypothyroidism is demonstrated, not based on its metabolic actions. Studies are warranted to determine whether a similar strategy for the heart’s endocrine system can advance the prevention and treatment of cardiometabolic disease. CMRU is strategically positioned to advance research toward this important strategic goal. 

  • Thomas Wang, M.D.
  • Ambarish Pandey, M.D.

Cobanoglu Lab

Both we (Cobanoglu et al., 2013) and others (Murphy, 2011) have reported that active machine learning driven experimentation can increase efficiency in the drug discovery process in the preclinical stage. We have a view towards integrating our computational work with an experimental pipeline. That is exactly why we are housed in a biomedical powerhouse, the UT Southwestern Medical Center, to execute this vision.

  • Murat Can Çobanoğlu, Ph.D.

Cobb Lab

The Cobb lab studies signal transduction mechanisms of protein kinases and how kinase structures lead to cell biological functions. We are particularly focused on the contributions of ERK MAP kinases to pancreatic beta-cell function and to lung cancers, and on the cell biological actions of WNK protein kinases.

  • Melanie Cobb, Ph.D.
Cancer Biology Cell and Molecular Biology

Collins Lab

We believe that understanding the basic biology of the schistosomes is key to developing the next generation of anti-schistosome drugs and vaccines. We also contend that by studying the basic biology of these fascinating organisms, we can better understand important basic biological processes common to all animals, including humans. For that reason, we study schistosomes from multiple angles using a variety of modern molecular approaches.of the lab. 

  • James J. Collins III, Ph.D.
Cell and Molecular Biology Genetics, Development and Disease

Condensate Catalyst Group

We unite researchers with diverse expertise in computational modeling, biochemical reconstitution, structural analysis of polymers, and cell biology to focus on three distinct condensates that are important for genome homeostasis.

  • Jeffrey Woodruff
  • Michael Rosen
  • Matthew Parker
  • Qian Cong
  • Ben Sabari
Cell and Molecular Biology Molecular Biophysics Molecular Biophysics Molecular Biophysics Molecular Biophysics Genetics, Development and Disease

Cong Lab

We mine large-scale data for biological discoveries.

  • Qian Cong, Ph.D.
Molecular Biophysics

Conrad Lab

RNA Biology Meets Herpes Virology

  • Nicholas K. Conrad, Ph.D.
Biological Chemistry Molecular Microbiology

Conzen Lab

 In prior work, my laboratory focused on identifying novel mechanisms of therapy-resistance and progression in breast, prostate and ovarian cancer. 

  • Suzanne D. Conzen, M.D.
Cancer Biology

Corbin Lab

The research focus in the Corbin lab investigates strategies that exploits the deviant metabolism of cancer cells (namely the reprogramming of lipid metabolism and altered redox biology) for therapeutic purposes.

  • Ian Corbin, Ph.D.
Biomedical Engineering Cancer Biology