Search Labs

Check out the latest research efforts of de Gracia Lux's Lab!

Through our expertise, our expert team is leading the charge to develop more effective alternate therapies for urinary tract infections.

The Dean Lab aims to develop and apply cutting-edge microscopy instrumentation and analyses to gain insight into otherwise intractable biological problems.

Proper control of metabolism is required for essentially every basic biological process. Altered metabolism at the cellular level contributes to several serious diseases including inborn errors of metabolism (the result of inherited genetic defects in metabolic enzymes that lead to chemical imbalances in children) and cancer. Our laboratory seeks to characterize these metabolic disorders, understand how they compromise tissue function, develop methods to monitor metabolism in vivo and design therapies to restore normal metabolism and improve health.

The HMG CoA reductase regulatory system researched by DeBose-Boyd Lab involves a complex, multivalent feedback mechanism that is mediated by sterol and nonsterol end-products of mevalonate metabolism.

The Dellinger Laboratory studies the development of the lymphatic vasculature and diseases caused by errors in the development of lymphatic vessels.

DeMartino Lab studies the biochemical mechanisms and the physiologic regulation of intracellular protein degradation.

We focus on neurodegenerative diseases linked to amyloid protein accumulation with the goal of developing mechanism-based diagnosis and therapy.

The Ding lab is led by Dr. Kan Ding, an Associate Professor and practicing neurologist who specializes in epilepsy. The lab concentrates on neurocritical care and post-traumatic epilepsy, with the goal of advancing strategies for diagnosis, treatment, and rehabilitation to improve care for those with epilepsy. 

We study the physical mechanisms that underlie animal development.

The Douglas lab seeks to understand how stress response pathways alter cell physiology, and ultimately influence the aging process and human disease.

The Elmquist laboratory uses mouse genetics to identify circuits in the nervous system that regulate energy balance and glucose homeostasis. We have developed unique mouse models allowing neuron-specific manipulation of genes regulating these processes.

Our laboratory is focused on the molecular control of lipid metabolism, particularly in the intestinal tract. We employ a variety of disciplines including molecular and cell biology, mouse models and organoid technologies. 

The Gospocic group studies how epigenetic pathways and gene expression regulate brain plasticity in the context of social behavior and aging by working with a unique ant species Harpegnathos saltator. We take a multidisciplinary approach and combine functional genomics, biochemistry, and behavioral assays in H. saltator, as well as the conventional Drosophila and mouse models to expedite genetic screening and provide evolutionary context to identified epigenetic pathways.

Specialty Areas: epigenetics, chromatin biology, gene regulation, social behavior, aging, neurodegeneration

Jan’s Lab is interested in understanding the dynamics of protein-RNA complexes during ribosome biogenesis. We are particularly focused on the roles of ATPases in coordinating ribosomal RNA processing and remodeling events, as well as the importance of these enzymes in signaling between the ribosome biogenesis pathway and the cell cycle machinery.

Learn more about the Families and Health Lab.

The Farrar Lab is interested in understanding how external signals regulate immune cell function and development. 

The long-term goal of Fiolka Lab's research is to develop and implement imaging technologies that provide unprecedented insight into cancer biology. 

We study the impact of disease-related hypoxic stress with aging upon synaptic plasticity, white matter connectivity, and cognitive performance.

Our laboratory studies the cell biology of viral-host interactions. 

Bacteria and phages are in everlasting conflict – constantly devising new genes, systems, and mechanisms to keep pace with their competitors. The Forsberg lab studies this “evolutionary arms race”, using high-powered selections to unearth new functions and careful experiments to reveal their mechanisms.

We investigate how the immune system and gut microbiota influence brain function and behavior. We use molecular, behavioral, anatomical, and immunological approaches in the lab. In parallel, we collaborate with clinical groups to examine the role of inflammatory and gut-brain mediators in psychiatric illness.

The Foster Lab research program represents a “best in class” translational research approach in an enriched, multidisciplinary environment. Foster's academic activities include a strong translational research program, a comprehensive teaching portfolio, science outreach, contribution to local, national, and international peer review and knowledge translation.

While cardiac and thoracic surgeries are often life-saving and may invoke life-changing improvements in health related quality of life, many patients also experience varying degrees of end organ injury and associated complications that can persist in the years following surgery. In 2014 Amanda Fox, M.D., M.P.H. initiated a genomics, biomarkers and outcomes research group at UTSW. This group values multi-specialty collaborations between anesthesiologists, surgeons cardiologists, radiologists, critical care physicians, biostatisticians, geneticists, bench scientists, and many other specialties.

The Fragile X Syndrome Research Center is a team of investigators from UT Southwestern and the University of California at Riverside. The Center supports three projects representing a multilevel, integrated approach that tests mechanisms of sensory neocortical dysfunction in fragile X syndrome (FXS) and pharmacological approaches to reduce the deficits.