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DeBerardinis Lab

Proper control of metabolism is required for essentially every basic biological process. Altered metabolism at the cellular level contributes to several serious diseases including inborn errors of metabolism (the result of inherited genetic defects in metabolic enzymes that lead to chemical imbalances in children) and cancer. Our laboratory seeks to characterize these metabolic disorders, understand how they compromise tissue function, develop methods to monitor metabolism in vivo and design therapies to restore normal metabolism and improve health.

  • Ralph DeBerardinis

Deisenhofer Lab

Our group is interested in analyzing three-dimensional structures of macromolecules using computational methods.

  • Johann Deisenhofer, Ph.D.
Molecular Biophysics

Dellinger Lab

The Dellinger Laboratory studies the development of the lymphatic vasculature and diseases caused by errors in the development of lymphatic vessels.

  • Michael Dellinger, Ph.D.
Genetics, Development and Disease

DeMartino Lab

DeMartino Lab studies the biochemical mechanisms and the physiologic regulation of intracellular protein degradation.

  • George N. DeMartino, Ph.D.
Protein Degradation
Biological Chemistry

Diamond Lab

We focus on neurodegenerative diseases linked to amyloid protein accumulation with the goal of developing mechanism-based diagnosis and therapy.

  • Marc Diamond, M.D.
tau protein Neurodegeneration alzheimer's disease parkinson's disease
Molecular Biophysics Neuroscience

Doubrovinski Lab

We study the physical mechanisms that underlie animal development.

  • Konstantin Doubrovinski

Douglas Lab

The Douglas lab seeks to understand how stress response pathways alter cell physiology, and ultimately influence the aging process and human disease.

  • Peter Douglas, Ph.D.
stress age lipid sensing concussion

Elliott Ross Lab

Our group is interested in how cells process information, particularly through heterotrimeric G proteins. 

  • Elliott M. Ross, Ph.D.
G proteins
Cell and Molecular Biology Molecular Biophysics

Elmquist Lab

The Elmquist laboratory uses mouse genetics to identify circuits in the nervous system that regulate energy balance and glucose homeostasis. We have developed unique mouse models allowing neuron-specific manipulation of genes regulating these processes.

  • Joel Elmquist, D.V.M., Ph.D.

Engelking Lab

Our laboratory is focused on the molecular control of lipid metabolism, particularly in the intestinal tract. We employ a variety of disciplines including molecular and cell biology, mouse models and organoid technologies. 

  • Luke Engelking, M.D.
SREBP polyposis colorectal cancer
Cell and Molecular Biology

Epigenetic Regulation of Social Brain

The Gospocic group studies how epigenetic pathways and gene expression regulate brain plasticity in the context of social behavior and aging by working with a unique ant species Harpegnathos saltator. We take a multidisciplinary approach and combine functional genomics, biochemistry, and behavioral assays in H. saltator, as well as the conventional Drosophila and mouse models to expedite genetic screening and provide evolutionary context to identified epigenetic pathways.

Specialty Areas: epigenetics, chromatin biology, gene regulation, social behavior, aging, neurodegeneration

  • Janko Gospocic, Ph.D.
research Epigenetics genetics aging
Genetics, Development and Disease

Erzberger Lab

Jan’s Lab is interested in understanding the dynamics of protein-RNA complexes during ribosome biogenesis. We are particularly focused on the roles of ATPases in coordinating ribosomal RNA processing and remodeling events, as well as the importance of these enzymes in signaling between the ribosome biogenesis pathway and the cell cycle machinery.

  • Jan Erzberger, Ph.D.
Molecular Biophysics

Farrar Lab

The Farrar Lab is interested in understanding how external signals regulate immune cell function and development. 

  • J. David Farrar, Ph.D.
clinical immunology Immunology cancer immunology Circadian rhythms allergy infectious disease

Fiolka Lab

The long-term goal of Fiolka Lab's research is to develop and implement imaging technologies that provide unprecedented insight into cancer biology. 

  • Reto Fiolka, Ph.D.
Biomedical Engineering

Floyd Hypoxia, Cognition, and Aging Lab

We study the impact of disease-related hypoxic stress with aging upon synaptic plasticity, white matter connectivity, and cognitive performance.

    • Thomas F. Floyd, MD
    Biomedical Engineering Neuroscience

    Fontoura Lab

    Our laboratory studies the cell biology of viral-host interactions. 

    • Beatriz M.A. Fontoura, Ph.D.
    Cancer Biology Molecular Microbiology

    Forsberg Lab

    Bacteria and phages are in everlasting conflict – constantly devising new genes, systems, and mechanisms to keep pace with their competitors. The Forsberg lab studies this “evolutionary arms race”, using high-powered selections to unearth new functions and careful experiments to reveal their mechanisms.

    • Kevin Forsberg

    Fox Lab

    While cardiac and thoracic surgeries are often life-saving and may invoke life-changing improvements in health related quality of life, many patients also experience varying degrees of end organ injury and associated complications that can persist in the years following surgery. In 2014 Amanda Fox, M.D., M.P.H. initiated a genomics, biomarkers and outcomes research group at UTSW. This group values multi-specialty collaborations between anesthesiologists, surgeons cardiologists, radiologists, critical care physicians, biostatisticians, geneticists, bench scientists, and many other specialties.

    • Amanda Fox, M.D., M.P.H.

    Fragile X Syndrome Research Center

    The Fragile X Syndrome Research Center is a team of investigators from UT Southwestern and the University of California at Riverside. The Center supports three projects representing a multilevel, integrated approach that tests mechanisms of sensory neocortical dysfunction in fragile X syndrome (FXS) and pharmacological approaches to reduce the deficits.

    • Kimberly Huber, Ph.D.

    Friedman Lab

    Our lab is interested in addressing a fundamental question of cell biology: How are organelles spatially organized?

    • Jonathan Friedman, Ph.D.
    Cell and Molecular Biology

    Fu Lab

    At the Fu Lab of human neuroscience we investigate the neural bases of cognitive control.

    • Zhongzheng Fu
    Biomedical Engineering Neuroscience

    Fujikawa Lab

    Obesity and metabolic diseases have been increasing at the alarming rate and threatening our health and economy over the world. However, we still don’t know much about how our metabolic homeostasis is regulated. Understanding the mechanism underlying the regulation of metabolism is a fundamental step towards designing new treatments for obesity and its associated diseases, and many other metabolic diseases

    • Teppei Fujikawa, Ph.D.

    Fujita Lab

    We are interested in the circuit mechanisms of how the cerebellum helps the brain to work better in health and disease.

    • Hirofumi Fujita, M.D., Ph.D.

    Galia Lab

    Our lab is studying novel regulatory mechanisms that control innate immunity in intestinal health and disease.

    • Liraz Galia, Ph.D.