The focus of the Obata Lab is to study how environmental signals (e.g., microbiota, diet, day/night cycles) shape intestinal neural circuits and immune cell networks. A variety of experimental techniques are used, including state-of-the-art imaging technologies, viral tracing of gut innervation, in vivo and ex vivo physiological assays, gnotobiotic systems and multi-omics technologies. The Obata lab is also interested in elucidating the molecular mechanisms of inter-organ communication, including the Gut-Brain axis.
The Oh lab is committed to elucidating how G protein-coupled Receptor (GPCR) works in regulating metabolism and identifying new avenues for developing therapeutics to treat metabolic syndromes such as type 2 diabetes, insulin resistance.
Dayoung Oh, Ph.D.
G protein-coupled receptortype 2 diabetesobesitymetabolic syndrome
Olson Lab studies muscle cells as a model for understanding how stem cells adopt specific fates and how programs of cell differentiation and morphogenesis are controlled during development.
The Orth lab is interested in elucidation the activity of virulence factors from pathogenic bacteria so that we can gain novel molecular insight into eukaryotic signaling systems.
The Osborne Lab focuses on how regulation of miRNA and mRNA controls the branching of developing cells, and how disregulation of these pathways contributes to aggressive tumor behavior.
The main research focus of the Otwinowski lab is on developing computational and statistical methods and protocols for macromolecular structure determination using X-ray crystallography.
The Pan laboratory uses Drosophila and mice as model systems to investigate size-control mechanisms in normal development and their pathological roles in cancer.
Duojia (DJ) Pan, Ph.D.
Cell and Molecular BiologyGenetics, Development and Disease
Our research is focused on mechanisms underlying acute kidney injury and sepsis. Our laboratory has implicated mitochondrial maintenance via PGC1alpha and NAD+ as a novel pathway for resilience against acute physiological stressors.
Dr. Park’s research focuses on the visual system and how the projection neurons in the retina, the retinal ganglion cell axons, find their targets and form synapses in the brain. He is investigating two key areas: 1) cellular and molecular mechanisms underlying the death of neurons and lack of regeneration in the central nervous system after injury and in degenerative diseases like glaucoma and 2) mechanisms by which neurons form proper connections with each other.
The Parkland Outcomes after Prematurity Study research group focuses on the short- and long-term effects of preterm birth, to improve lifelong health outcomes for current and future patients.
Kara Goss, M.D.
Charles Rosenfeld, M.D.
Luc Brion, M.D.
Prematuritylate outcomesparkland nicu databaseneonatal care
Our laboratory has a particular interest in hepatic metabolism and its regulation by the immune system. We utilize genetic, epigenetic and proteomic approaches, combined with detailed physiological studies, to understand the complex mechanisms that causally link inflammation to metabolic dysfunction in obesity and fatty liver disease.
Dr. Pawlowski's laboratory studies how mutant genes affect the structure of the Organ of Corti, and searches for treatments against otitis media and infection of cochlear implants.
Preventing Cognitive Decline by Reducing Blood Pressure Target Trial (PCOT) Researchers at UT Southwestern Medical Center are doing a study to prevent cognitive decline in adults by reducing blood pressure.
The mission of the Pedrosa Lab is to develop and implement new imaging methods that facilitate better morphologic and pathophysiologic characterization of diseases in the body for improved patient outcomes
Petroll Lab applies engineering approaches and design principles to the investigation of fundamental clinical and biological problems in ophthalmology, while providing training to graduate students, medical students, and post-docs.
