The significance of our research is to show effective anti-Aβ42 antibody production in large animals and safety of DNA Aβ42 immunotherapy in these models to proceed with vaccination in patients at risk for Alzheimer’s disease.
Research in the Rothermel Laboratory focuses on deciphering the molecular mechanisms that control cardiac structure and function during normal development and in response to pathological stress.
Our lab specializes in clinical and research informatics, with a diverse portfolio of projects that leverage electronic health record (EHR) data and multimodal research data to enhance clinical care and advance research in the neurosciences.
The Ruan Lab focuses its research on developing statistical methods and computational algorithms for multi-omics data with applications in complex human diseases.
We study how biomolecular condensates organize gene regulation.
Saelices Lab employs crystallography and cryo-EM to study amyloid deposition and design anti-amyloid tools.
The Saha Lab.
Sakano Lab investigates FMRP's influence on auditory brainstem development in Fragile X Syndrome. Using a mouse model, we examine gene expression and its potential link to autism, auditory processing, hyperacusis, and tinnitus.
Our mission is to advance biomedical knowledge in Multiple Sclerosis and support investigators in Neurology using best practices and comprehensive biostatistics expertise.
We seek to understand how RNA/protein assemblies control cellular states, and how related pathways are hijacked by diseases of aging.
The Sandstrom Lab works to identify the fundamental molecular mechanisms through which the immune system can recognize pathogens and stress.
Satterthwaite Lab studies the signals that control B lymphocyte development, activation, and differentiation into antibody-secreting plasma cells, both normally and in autoimmune diseases such as lupus. We hope that by defining these events, we can reveal new approaches to modulate antibody responses therapeutically.
The Saunders Lab aims to advance our understanding of the bacterial domain of life using high throughput genetics to map the molecular interactions that underly cellular physiology.
The Saxena lab's research interests include Icodextin in high peritoneal transporters; Kremezin study in patients with chronic kidney disease; SV40 in focal segmental glomerulosclerosis; molecular studies in lupus nephritis.
The main focus in our laboratory is the identification and physiological characterization of adipocyte-specific gene products and the elucidation of pathways that are an integral part of the complex set of reactions that drive adipogenesis.
The Schoggins Lab studies innate immunity at the virus-host interface. We are interested in mechanisms of cellular antiviral defense and the role these responses play during viral disease.
What are the causes and consequences of cytoskeletal diversification?
The Seemann Lab studies the molecular mechanisms governing the function and inheritance of the mammalian Golgi apparatus.
The Sguigna lab investigates the visual system in multiple sclerosis, and other neurological conditions, with the intent of leveraging technologies to further science both diagnostically and therapeutically.
We aim to characterize the ways in which reward systems vary from individual to individual and understand how this variation determines propensity for depression and addiction-like behavior.
The Shahmoradian lab investigates the roles of domain-specific neuronal proteins using advanced cryo-imaging techniques to understand their impact on cellular dynamics and neurological health.
Our lab researches Cerebellar Dysfunction, Brainstem Dysfunction, High-Throughput Screen, and Human Studies.
The BraNiC lab is dedicated to developing advanced methods for assessing the potential for brain function recovery after severe brain injuries.
The Sharma lab is interested in investigating intermediary metabolism utilizing carbon-13 stable isotope tracers in conjunction with magnetic resonance spectroscopy (MRS), magnetic resonance imaging (MRI), and mass spectrometry (MS).
The overall goal of our laboratory is to discover the processes in endothelial cells that govern cardiovascular and metabolic health and disease.
