Search Labs

The major interest of my lab is to understand the transcriptional regulatory mechanisms involved in human diseases with a focus on cardiovascular diseases and cancer. 

Dr. LoBue's BRAIN lab, short for Brain Aging, Injury, and Modulation Lab, has two lines of research in the area of aging and neurodegenerative diseases. The lab investigates the later-in-life effects of traumatic brain injury, which involves understanding the potential risk associated with developing dementia and the underlying biological pathways. The lab also studies the effects of noninvasive brain stimulation in Alzheimer’s disease and related disorders with the goal of informing the development of new treatments.

Our mission is to better unravel the causes and mechanisms underlying tremor disorders as well as understand the clinical features of these disorders.

The Louros Lab uses a hybrid approach combining molecular biophysics, structural biology, and bioinformatics to investigate protein stability, misfolding, and aggregation, with a particular interest in neurodegenerative diseases.

For decades, the field of tuberculosis (TB) immunology has focused on T cell mediated protection, yet Mycobacterium tuberculosis (Mtb) still impacts one in four individuals worldwide today.

The Luo lab studies hypoxia stress in human cancers with a focus on epigenetic and metabolic alterations. 

The Luo lab studies the molecular mechanisms of intracellular signal transduction, focusing on the spindle checkpoint and the Hippo tumor-suppressor pathway.

The research interests of the Lux Lab lie in the development of novel nanomedicine platforms to diagnose and treat disease in vivo noninvasively.

The Ly Laboratory studies how cell cycle defects and mitotic errors shape the complex mutational landscape of human cancer genomes.

Our research aims to obtain a comprehensive picture of how genomic stability and chromatin dynamics affect neuronal functions, including learning behaviors, and to apply this knowledge to combat neurological disorders.

Using novel multi-omics approaches and model systems to treat pancreatic cancer

We study the molecular events that drive this process in a term pregnancy and how perturbation of these processes contribute to premature birth.

Medical Artificial Intelligence and Automation

Dr. Maldjian's ANSIR Lab is devoted to the application of novel image analysis methods (e.g. diffeomorphic registration, machine learning, graph theory, ASL) to research studies, as well as to robust clinical translation of these techniques.

We study how disseminated cancer cells survive and give rise to overt metastatic lesions.

Malloy Lab has all the tools necessary for students at all levels to lean about metabolic imaging of physiology and disease and I am excited to participate.

Malter Lab focuses on exploring and characterizing intracellular signaling pathways in the immune and nervous systems and identifying how defects/abnormalities can lead to disease.

The Mangelsdorf/Kliewer Lab studies two signal transduction pathways that offer new therapeutic potential for treating diseases such as diabetes, obesity, cancer, and parasitism.

The overall focus of the Ram Mani Lab is to study the molecular genetic and epigenetic events associated with cancer development.

The Marciano laboratory investigates fundamental aspects of kidney development and regeneration, in both health and disease.

Our laboratory is interested in understanding how the ubiquitin-mediated protein degradation regulates gene expression and how failure of these pathways contributes to developmental disorders and diseases, such as neurodegeneration and cancer.

We are interested in understanding the deregulation of epigenetic and transcriptional pathways in human disease and in finding small molecules with therapeutic potential to normalize these gene expression patterns. 

The overarching goal of Mason Lab's research is the development of prognostic imaging signatures defining biomarkers of disease progression and response to therapy.

We aim to elucidate the role of the innate immune system in damage and repair following ischemic and hemorrhagic insults to the brain. We are specifically focused on innate immune drivers of secondary injury following aneurysmal subarachnoid hemorrhage and the immune response triggered by acute intracranial pressure spikes during aneurysm rupture. We also look into promoting recovery after ischemic stroke by reprogramming microglia and peripheral myeloid cells to drive repair. In addition, we are pursuing the development of therapeutics for intraarterial immunomodulation for chronic subdural hemorrhage.