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The Mangelsdorf/Kliewer Lab studies two signal transduction pathways that offer new therapeutic potential for treating diseases such as diabetes, obesity, cancer, and parasitism.

The overall focus of the Ram Mani Lab is to study the molecular genetic and epigenetic events associated with cancer development.

The Marciano laboratory investigates fundamental aspects of kidney development and regeneration, in both health and disease.

Our laboratory is interested in understanding how the ubiquitin-mediated protein degradation regulates gene expression and how failure of these pathways contributes to developmental disorders and diseases, such as neurodegeneration and cancer.

We are interested in understanding the deregulation of epigenetic and transcriptional pathways in human disease and in finding small molecules with therapeutic potential to normalize these gene expression patterns. 

We aim to elucidate the role of the innate immune system in damage and repair following ischemic and hemorrhagic insults to the brain. We are specifically focused on innate immune drivers of secondary injury following aneurysmal subarachnoid hemorrhage and the immune response triggered by acute intracranial pressure spikes during aneurysm rupture. We also look into promoting recovery after ischemic stroke by reprogramming microglia and peripheral myeloid cells to drive repair. In addition, we are pursuing the development of therapeutics for intraarterial immunomodulation for chronic subdural hemorrhage.

The McAdams Lab at UT Southwestern uses neuroimaging and behavioral measures to investigate the connections between social, psychological, and biological aspects of eating disorders.

Our goal is to identify the metabolic mechanisms that push cells to become cancerous and find new ways to inhibit them.

The McFadden lab uses genetically engineered mice and human cancer cells to identify new genes and small molecules that regulate cancer cell growth.

The Mendell laboratory investigates fundamental aspects of post-transcriptional gene regulation, noncoding RNA regulation and function, and the roles of these pathways in normal physiology, cancer, and other diseases.

The mission in the Meng Lab is to develop a better understanding of how fundamental alterations to cell polarity contribute towards development of invasive disease in kidney cancer.

Michaely Lab focuses on the function of the proteins that control plasma membrane function. We have on-going projects investigating ARH/LDLR endocytosis and caveolae signal transduction. 

Minassian Lab has been involved in the identification and co-discovery of the causative gene mutations in over 20 different childhood neurological diseases. 

The main focus of the Minna Lab is translational (“bench to bedside”) cancer research aimed at developing new ways to diagnose, prevent, and treat lung cancer based on a detailed understanding of the molecular pathogenesis of lung cancer.

Mirpuri Lab is focused on neonatal innate immunity and the role of maternal diet (mHFD), dietary metabolites and innate lymphoid cells in offspring outcomes.

Our research focuses on how mitochondria are embedded in normal cellular function.

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Dr. Mizuno's laboratory studies autonomic control of the cardiovascular system, particularly the underlying alterations in circulatory control in type 1 or type 2 diabetes and Alzheimer’s disease.

The Moe Lab specializes in translational pathophysiology that spans from individual molecules, in vitro cell models, in vivo animal models, to metabolic human studies. 

The Molecular Imaging and Precision Medicine Lab has four Technology Research and Development (TR&D) projects that provide a platform on which new technology is developed and disseminated. The TR&Ds are complementary and integrated and extend from the development of reagents to detect and promote an immune reactive tumor microenvironment to the synthesis of nanodrones to treat cancer and combined small-molecule diagnostic and therapeutics (theranostic agents). We focus on generation of next-generation precision platforms, tools and techniques for tackling problems at the forefront of biomedical research with a focus on those that will lead to near-term translation.

The Monson Lab is dedicated to understanding how B cells and T cells impact pathology of disease in the central nervous system.

We develop the theory and application of deep learning to improve diagnoses, prognoses and therapy decision making.

Mootha Lab uses human genetics and genomics to understand the molecular basis of Fuchs' endothelial corneal dystrophy and develop novel therapeutic strategies.