The Tong lab studies the cellular and molecular mechanisms of cardiovascular diseases associated with systemic metabolic disorders, particularly heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF), with an eye toward translating these findings into innovative solutions to clinical problems.
Dan Tong, M.D., Ph.D.
Heart Failure with Preserved Ejection FractionAtrial FibrillationClonal Hematopoiesis
Cell and Molecular BiologyGenetics, Development and Disease
We investigate genetic and molecular basis of phenotypic diversity observed in nature by using a range of methodologies such as whole genome sequencing, fluidics, long-term evolution experiments, and large-scale combinatorial mutagenesis.
My research interests include prevention of progression of renal diseases, diagnoses, and management of lipid disorders in renal disease, hypertensive nephrosclerosis, the role of angiotensin II converting enzyme inhibitors, and angiotensin II receptor blockers in renal disease.
The Center for Depression Research and Clinical Care (CDRC) is nationally recognized for its cutting-edge research in unipolar and bipolar depression. The research conducted within the center brings better understanding of the causes of depression, identifies effective new treatments, and improves existing ones.
The Tu Lab is investigating how a variety of cellular processes and decisions are coordinated with metabolic state, and how the dysregulation of these mechanisms might be linked to disease and aging.
The Turer Lab is interested in finding genes with novel functions in intestinal immune homeostasis. Our projects generally involve a mix of experimental approaches examining both the intestinal epithelium as well as hematopoietic causes of intestinal inflammation.
Children with in-born errors of immunity are prone to life-threatening viral, bacterial, and fungal infections. We study the causes of their immune system problems, combining clinical insights and mouse models genocopying the various mutations. This work includes a profiling of immune responses to infections (e.g., COVID-19) in normal healthy individuals along with different patient populations (e.g. 22q11.2 deletion syndrome).
Discover the Miguel Vazquez Lab at UT Southwestern, leading research in chronic kidney disease, diabetes, and hypertension. Learn about the IDC-Pieces study—a large, NIH-supported clinical trial improving chronic disease management through innovative care models and technology.
Dr. Vega and co-workers have discovered three other causes of high LDL. First, she found that some patients have abnormal LDL particles that cannot be removed from circulation because the abnormal LDL does not recognize the receptors.
We leverage our knowledge of fundamental neuroscience to create wearable bidirectional brain-machine interfaces for the restoration and assistance of upper limb sensation and movement in people with paralysis.
The Vernino Lab focuses on the mechanisms of autoimmune disorders of the nervous system, especially those associated with neurological autoantibodies. We use a variety of techniques including histology, and immunology. This research is complemented by clinical therapeutic trials studying novel treatments for autoimmune encephalitis and autonomic disorders.
The main focus of the Vinogradov Lab is developing MRI methods that are based on the intrinsic biochemical processes and physical properties of the tissue: chemical exchange rearrangements, molecular networks, and relaxation.
Explore the Vongpatanasin Lab at UT Southwestern, specializing in research on neural control of blood pressure, autonomic dysfunction, and the impact of nutrition and hormones on cardiovascular health. Discover clinical studies, lab members, and featured publications advancing hypertension and autonomic research.
The research of Wai Lab focuses on female pelvic floor disorders and understanding the functional anatomy of the lower urinary tract and anal sphincter.