The Wang lab applies single-molecule fluorescence biophysical, quantitative biochemical, structural, and genetics approaches to unravel the intricate relationships between structure, dynamics and function in complex dynamic biological systems. Our primary goal is to understand the dynamic mechanisms of cytosolic and mitochondrial protein synthesis and how they are dysregulated in human diseases.
We study ion channel clusters. To study such clusters without the complications arising from the complex cellular environment, components from cells are purified and studied in isolation.
Dr. Waugh is a physician-scientist whose research focuses on the structural brain abnormalities that lead to dystonia, a movement disorder that leads muscles to twist and contort into painful positions.
Located in the Department of Ophthalmology, the Wert laboratory studies the post-mitotic neuronal cells of the retina, particularly the photoreceptor cells. Our goal is to discover and understand the mechanisms underlying retinal degenerative disease, and to provide novel therapeutics for these complex degenerative disorders using gene therapy and genome engineering technologies, human stem cell transplantations, and metabolic rescue.
We focus on the discovery of targeted therapies for major drivers of cancer using protein chemistry, enzymology, structural biology, informatics and cell biology. Some of our favorite targets are RAS and kinase proteins.
The Whitehurst Lab uses RNAi-based functional genomics to identify gene products that support viability and/or modulate chemotherapeutic sensitivity in tumor cells.
We are interested in understanding at a cellular level the neural control of energy balance and glucose metabolism, and elucidating how these events may participate in human disease.
The Concussion, Acquired Brain Injury, and Neurodegeneration (CABIN) Laboratory, led by Kristin Wilmoth, Ph.D., investigates best practices for assessment and treatment of concussion and more severe traumatic brain injury, other acquired brain injuries such as stroke, and neurodegenerative conditions such as Alzheimer's disease.
We are interested in the function of chromatin regulation of signaling pathways important for neural development, brain tumor growth and autism pathogenesis.
The Wu Laboratory mainly focuses on using stem cell models to gain novel insights in mammalian development and develop regenerative medical applications.
Our work advocates for the wider adoption of alteplase, antiplatelet therapy in ischemic stroke, secondary stroke prevention, off-label guidelines for those with acute ischemic stroke, and more.