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The Rosa-Neto Lab studies the structural changes that occur in the brain as a result of neurodegenerative disease, such as Alzheimer’s disease. 

The Center for Depression Research and Clinical Care (CDRC) is nationally recognized for its cutting-edge research in unipolar and bipolar depression. The research conducted within the center brings better understanding of the causes of depression, identifies effective new treatments, and improves existing ones.

Translational Research in UltraSound Theranostics (TRUST) Lab at UT Southwestern

Tsai Lab studies the cellular and molecular mechanisms of synapse and neural circuit development.

Using patient-specific stem cells, tissue engineering, and omics technologies to develop precision medicine for cardiovascular disease.

The Tu Lab is investigating how a variety of cellular processes and decisions are coordinated with metabolic state, and how the dysregulation of these mechanisms might be linked to disease and aging.

The Turer Lab is interested in finding genes with novel functions in intestinal immune homeostasis. Our projects generally involve a mix of experimental approaches examining both the intestinal epithelium as well as hematopoietic causes of intestinal inflammation.

spinal cord injury, wound, pressure ulcer

The goal of the Ufret-Vincenty Lab is to develop therapeutic strategies for age-related macular degeneration (AMD).

Children with in-born errors of immunity are prone to life-threatening viral, bacterial, and fungal infections. We study the causes of their immune system problems, combining clinical insights and mouse models genocopying the various mutations. This work includes a profiling of immune responses to infections (e.g., COVID-19) in normal healthy individuals along with different patient populations (e.g. 22q11.2 deletion syndrome).

The Varadarajan Lab is interested in rebuilding neural circuits and restoring sensory function impaired by injury or disease.

Discover the Miguel Vazquez Lab at UT Southwestern, leading research in chronic kidney disease, diabetes, and hypertension. Learn about the IDC-Pieces study—a large, NIH-supported clinical trial improving chronic disease management through innovative care models and technology.

Dr. Vega and co-workers have discovered three other causes of high LDL. First, she found that some patients have abnormal LDL particles that cannot be removed from circulation because the abnormal LDL does not recognize the receptors. 

We leverage our knowledge of fundamental neuroscience to create wearable bidirectional brain-machine interfaces for the restoration and assistance of upper limb sensation and movement in people with paralysis.

The Vernino Lab focuses on the mechanisms of autoimmune disorders of the nervous system, especially those associated with neurological autoantibodies. We use a variety of techniques including histology, and immunology.  This research is complemented by clinical therapeutic trials studying novel treatments for autoimmune encephalitis and autonomic disorders.

The main focus of the Vinogradov Lab is developing MRI methods that are based on the intrinsic biochemical processes and physical properties of the tissue: chemical exchange rearrangements, molecular networks, and relaxation.

The Volk Lab's research focuses on the hippocampus as they research how the brain balances dynamic learning and persistent memory.

Explore the Vongpatanasin Lab at UT Southwestern, specializing in research on neural control of blood pressure, autonomic dysfunction, and the impact of nutrition and hormones on cardiovascular health. Discover clinical studies, lab members, and featured publications advancing hypertension and autonomic research.

The research of Wai Lab focuses on female pelvic floor disorders and understanding the functional anatomy of the lower urinary tract and anal sphincter.

The Wakeland Lab utilizes state-of-the-art genomic strategies to investigate the diversity of the human and mouse immune systems. 

The Wang Lab uses chemical biology tools to study the molecular mechanisms underlying interesting bacterial behaviors.

The broad research interest of Fei Wang lab is in dissecting molecular mechanisms of essential cellular events in eukaryotic cell development. Currently, my laboratory investigates how cells preserve the fidelity of gametogenesis under environmental and physiological stress. Gametogenesis, the process by which diploid precursors undergo meiosis and differentiation to produce haploid gametes, is remarkably sensitive to temperature and other stressors. Even mild perturbations tolerated by mitotically dividing cells can disrupt meiosis, leading to infertility or defective gametes. This heightened sensitivity reflects the competing demands faced by germ cells: they must complete complex developmental transitions while responding flexibly to environmental challenges. The mechanisms that safeguard meiotic integrity under such conditions have long remained poorly understood. In somatic cells, two conserved pathways—stress granules (SGs) and autophagy—serve as major quality-control systems under stress. SGs sequester untranslated mRNAs and RNA-binding proteins to pause translation and preserve key transcripts, while autophagy recycles damaged or unneeded components through autophagosome-mediated degradation, restoring proteostasis and energy balance. How these systems cooperate during meiosis, when transcriptional and translational reprogramming, organelle remodeling, and proteome renewal occur simultaneously, has remained largely unexplored.

Using Saccharomyces cerevisiae (budding yeast) as a powerful model, my group integrates genetics, biochemistry, live-cell imaging, proteomics, and computational approaches to uncover how autophagy and RNA regulation ensure gamete quality under stress. Supported by Welch and NIGMS(R01 and R35) fundings and an endowed scholarship to Dr. Fei Wang (Nancy Cain and Jeffrey A. Marcus Scholar in Medical Research, in Honor of Dr. Bill S. Vowell), our research has defined a unified quality-control network that integrates autophagy, RNA regulation, and stress response to preserve reproductive fidelity. 

We apply advanced MRI technologies to study many different diseases.

The Wang Lab investigates the roles of genetic factors and transcriptional regulation in skeletal diseases and bone cancer.