The Wang lab applies single-molecule fluorescence biophysical, quantitative biochemical, structural, and genetics approaches to unravel the intricate relationships between structure, dynamics and function in complex dynamic biological systems. Our primary goal is to understand the dynamic mechanisms of cytosolic and mitochondrial protein synthesis and how they are dysregulated in human diseases.
Our research focuses on how the conserved signaling pathways that underlie normal skin development are altered during the development of non-melanoma skin cancers and inflammatory skin disease.
Our research revolves around using state-of-the-art bioinformatics and biostatistics approaches to study the implications of tumor immunology for tumorigenesis, metastasis, prognosis, and treatment response in a variety of cancers.
We study ion channel clusters. To study such clusters without the complications arising from the complex cellular environment, components from cells are purified and studied in isolation.
The Wang Lab studies neurodegeneration and cell death induced by brain injury, mitochondrial dysfunction, and/or genome instability.
Dr. Waugh is a physician-scientist whose research focuses on the structural brain abnormalities that lead to dystonia, a movement disorder that leads muscles to twist and contort into painful positions.
The over-arching theme of the Weaver Lab is to deeply understand how proteolytic factors mediate diverse physiological functions.
The Welch Lab has a primary interest in developing materials and medical devices for use in treatment of congenital heart disease.
The Wert laboratory studies the post-mitotic neuronal cells of the retina, particularly the photoreceptor cells. Our goal is to discover and understand the mechanisms underlying retinal degenerative disease, and to provide novel therapeutics for these complex degenerative disorders using gene therapy and genome engineering technologies, human stem cell transplantations, and metabolic rescue.
We focus on the discovery of targeted therapies for major drivers of cancer using protein chemistry, enzymology, structural biology, informatics and cell biology. Some of our favorite targets are RAS and kinase proteins.
The Wetzel Lab targets critical steps in the parasite’s life cycle in order to develop therapeutics for Leishmaniasis.
White, Perrin Lab - Labs - Research
The Whitehurst Lab uses RNAi-based functional genomics to identify gene products that support viability and/or modulate chemotherapeutic sensitivity in tumor cells.
We are interested in understanding at a cellular level the neural control of energy balance and glucose metabolism, and elucidating how these events may participate in human disease.
Wilson Lab
Scientists in the Center for Pediatric Bone Biology and Translational Research work to discover the underlying causes of poorly understood musculoskeletal disorders in children, and to understand the fundamental steps that lead to disease.
We use live-cell microscopy, nano-rheology, and synthetic biology to understand oocyte ageing, embryogenesis, and cancer onset.
In our laboratory, we utilize molecular and cellular approaches to decipher mechanisms of extracellular matrix remodeling of the female reproductive tract in both physiologic states (e.g., during pregnancy, parturition, and the puerperium) and pathologic conditions (pelvic organ prolapse, urinary incontinence, and injury of the external anal sphincter).
The Wu Laboratory mainly focuses on using human primary nasal and oral epithelium culture to gain novel insights in virus-host interactions.
We are interested in the function of chromatin regulation of signaling pathways important for neural development, brain tumor growth and autism pathogenesis.
The Wu Laboratory mainly focuses on using stem cell models to gain novel insights in mammalian development and develop regenerative medical applications.
The long-term goal of our lab is to understand the functions of ecDNA and how ecDNA is maintained in cancer.
The Wu Lab focuses on understanding the molecular pathways that govern T cell differentiation and function during infection and cancer.
