Search Labs

I am interested in developing computational models and algorithms for big data to predict patients' outcomes, which can help clinicians to tailor treatment plans for individual patients.

The focus of our current research is the biochemistry and molecular characterization of ABCG5/ABCG8 transporter, aiming at understanding the mechanism by which this transport system operates to translocate cholesterol cross membranes.

Our team is interested in developing computational models to predict patient outcomes, which will allow clinicians to tailor treatment plans for individual patients.

Welcome to the Xing Lab in the Eugene McDermott Center for Human Growth and Development!

Dr. Xu’s primary research interests include tissue engineering of the vocal fold, anatomy and physiology of voice production, and laryngeal biomechanics. 

The lab focuses on developing bioinformatics algorithms and deep learning models to identify new disease genes and therapeutic targets for human diseases, as well as development and maintenance of data management system for genomic and clinical databases.

Wei Xu Lab strives to achieve a mechanistic understanding of fundamental cognitive processes, explore their impairments in neuropsychiatric disorders, and discover innovative treatments for these conditions. 

Our lab focuses on the neural dynamics for successful memory access and retrieval during episodic working memory tasks to elucidate the neural circuit mechanism in the hippocampal-cortical network.

Since I began studying the biological rhythms of insects during graduate school, I have been fascinated with the accuracy of the circadian timing system and the phenomenal influence of the circadian clock on almost all biological activities. This fascination has fueled my interest in learning about circadian rhythms for more than a quarter of a century.

The Yan Lab studies molecular mechanisms of innate immunity in infection, autoimmune diseases, cancer immunology and neurodegenative diseases.

The Yang Lab aims to overcome clinical unmet needs and help patients by developing and validating advanced radionuclide imaging technologies for positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging. Deep learning is an important engine for overcoming the current limitations (low spatial resolution, slow data acquisition, etc.) of PET and SPECT imaging. . 

Yao Laboratory identifies molecular and cellular mechanisms that determine the efficacy of vaccines and immunotherapies against infectious diseases and cancers.

The Ye Lab is broadly interested in lipid-mediated signaling reactions.

We study how the membrane lipid phosphatidylinositol 4,5 bisphosphate (PIP2) regulates the actin scaffold in proliferating and autophagic cells.

We are interested in how metabolism regulates various behaviors. We use two invertebrate model systems of C. elegans and D. melanogaster, ultimately aiming to unveil conserved neuro-molecular mechanisms throughout animals including mammals.

Yu Lab is interested in the molecular and cellular basis of Alzheimer’s disease, amyotrophic lateral sclerosis, frontotemporal dementia, and related neurodegenerative disorders.

The Yu lab focuses on anisosomes, TDP-43 aggregation, and molecular glue in studying the mechanisms behind age-related neurodegeneration.

The Yue lab studies molecular and cellular mechanisms underlying musculoskeletal regeneration and tumorigenesis, and develops novel immunotherapeutics to treat patients.

Zaki Lab's research focuses on the the study of gastrointestinal inflammation and cancer.

Zaman’s Lab focuses on the design and development of novel cutting-edge multi-mode imaging systems to overcome current limitations in clinical systems. Most recent research project is involved with the design and developed of a multimode catheter-based imaging system called a Circumferential Intravascular Radioluminescence Photoacoustic Imaging (CIRPI) for early detection of thin-cap-fibro-atheroma (TCFA), the underlying causes of coronary artery disease, one of the leading causes of morbidity and mortality in the USA and worldwide. Further, the CIRPI system characterizes the plaques based on disease tissue compositions to unravel their complex structures. This CIRPI system integrates optical, photoacoustic, radioluminescence and ultrasound imaging. We seek to better understand the underlying causes of the disease mechanisms. We are dissecting the role of TCFA perturbations on vascular wall processes during atherosclerosis progression. Our lab also studying novel molecular imaging methods to study coronary arterial disease, carotid stenosis, and myocardial ischemia in subcellular level.

Zang Lab investigates the molecular mechanisms underlying the pathogenesis of sepsis. We use the heart as a model, since cardiac dysfunction is a vital component of multi-organ failure during sepsis.

Zeng Lab is interested in understanding at the molecular level key questions lying at the interface between biochemistry, cell biology, metabolic and neural physiology, including the bidirectional communication between autonomic neurons and adipocytes, the molecular basis of the phenotypic plasticity, or the lack of, in brown, beige and white adipocytes, and roles of uncharacterized enzymatic pathways in adipose thermogenesis.

Zhan Lab's mission is to advance medical genetics research through cutting-edge statistic models and computationally efficient software tools

The lab's long-term goal is to illuminate the function of immune surface molecules and to open up a new research field at the interface of cancer, immunology, and stem cell research. Zhang Lab also actively develops novel therapies for cancer treatment.

Zhang (Chun-Li) Lab research focuses on cellular plasticity in the adult nervous system and modeling human neurodegenerative diseases. We use cell culture and genetically modified mice as model systems. Molecular, cellular, electrophysiological, and behavioral methods are employed.